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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.
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Effects of caloric restriction and exercise on age-related, chronic inflammation assessed by C-reactive protein and interleukin-6.

机译：通过C反应蛋白和白介素6评估热量限制和运动对与年龄相关的慢性炎症的影响。

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摘要

Chronic inflammation is associated with the aging process and numerous age-related pathologies. We evaluated the effects of age, caloric restriction (CR), and exercise on plasma C-reactive protein (CRP), interleukin-6, and total antioxidant capacity in Fisher 344 rats. The inflammatory markers were analyzed using enzyme-linked immunosorbent assays (ELISA), while total antioxidant potential was determined by a spectrophotometric method. An increase in circulating levels of CRP with age was attenuated with long-term 40% CR; short-term 40% CR in young animals also reduced CRP concentration compared to age-matched controls. Lifelong exercise with 8% CR showed a marked decrease in CRP levels compared to 8% CR controls and an even greater reduction compared to ad libitum-fed rats. Plasma interleukin-6 levels remained unchanged with age, CR, and exercise, whereas inflammation levels showed an inverse association with plasma antioxidant status. These studies highlight the anti-inflammatory effects of CR and exercise.
机译：慢性炎症与衰老过程和许多与年龄有关的病理相关。我们评估了年龄，热量限制（CR）和运动对Fisher 344大鼠血浆C反应蛋白（CRP），白介素6和总抗氧化能力的影响。使用酶联免疫吸附测定（ELISA）分析炎症标记，同时通过分光光度法确定总抗氧化剂潜力。长期40％CR可使CRP的循环水平随年龄增加而减弱;与年龄相匹配的对照组相比，幼小动物的短期40％CR还降低了CRP浓度。与8％CR对照组相比，使用8％CR的终身运动显示CRP水平显着降低，而与随意喂养的大鼠相比，其降低幅度更大。血浆白细胞介素6水平随年龄，CR和运动而保持不变，而炎症水平与血浆抗氧化剂状态呈负相关。这些研究突出了CR和运动的抗炎作用。

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