...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age-related accumulation of a novel CD44 + CD25lowgammadelta T-cell population in hematopoietic organs of the mouse.
【24h】

Age-related accumulation of a novel CD44 + CD25lowgammadelta T-cell population in hematopoietic organs of the mouse.

机译：小鼠造血器官中新型CD44 + CD25lowgammadelta T细胞群体的年龄相关积累。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We discovered a novel population of gammadelta T cells in the mouse that accumulates with age in hematopoietic organs, but not in epithelia. These cells are CD25low (an unusual phenotype for gammadelta T cells in the mouse); express higher levels of TCRgammadelta and CD44 than do CD25- gammadelta T cells; mainly express Vgamma2, Vgamma3, and Vgamma4 chains; and are largely quiescent. A very similar cell population appears in the late stages of fetal thymus organ cultures, suggesting that the accumulation of CD44 + CD25lowTCRgammadelta + cells is a response to stress induced by aging in vivo or by culture in vitro. The precursors of CD44 + CD25lowTCRgammadelta + cells are generated during fetal or very young adult life, as this population was undetectable in aged recipients of bone marrow from old or young donors. CD44 + CD25lowTCRgammadelta + cells may be a biomarker of aging, but could also play a role in the inflammatory changes that accompany aging.
机译：我们在小鼠中发现了一个新的γ-T细胞群体，随着年龄的增长在造血器官中积累，但在上皮细胞中却没有。这些细胞为CD25low（小鼠中γδT细胞的异常表型）。与CD25-γT细胞相比，TCRγδ和CD44的表达水平更高;主要表达Vgamma2，Vgamma3和Vgamma4链;并且基本上是静止的。胎儿胸腺器官培养的后期出现了非常相似的细胞群，这表明CD44 + CD25lowTCRgammadelta +细胞的积累是对体内或体外培养衰老诱导的应激反应。 CD44 + CD25lowTCRgammadelta +细胞的前体是在胎儿或非常年轻的成年期间产生的，因为在来自老年或年轻供体的老年骨髓接受者中无法检测到该群体。 CD44 + CD25lowTCRgammadelta +细胞可能是衰老的生物标志物，但也可能在伴随衰老的炎症变化中起作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号