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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Caloric restriction and aging revisited: the need for a geometric analysis of the nutritional bases of aging.
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Caloric restriction and aging revisited: the need for a geometric analysis of the nutritional bases of aging.

机译：重新讨论了热量限制和衰老：需要对衰老的营养基础进行几何分析。

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摘要

One of the most important findings in the field of the biology of aging has been the demonstration that modest dietary restriction extends life span in a wide range of taxonomically disparate organisms. There is currently a debate as to whether longevity is prolonged because of caloric restriction or due to more specific nutrient effects. Recent advances in nutritional research, notably the development of state-space geometric models, the Geometric Framework (GF), offer new opportunities to disentangle the effects of calories and nutrients. We begin by introducing these models, then set out the four questions that must be addressed to establish the relationship between nutrition and aging and indicate how the GF might help in answering these. We next provide an exemplar experimental protocol and consider some practical challenges to implementing the GF. Our conclusion is that Drosophila provides the most suitable system for an initial study.
机译：衰老生物学领域最重要的发现之一就是证明适度的饮食限制可延长各种不同分类生物的寿命。当前关于是否由于热量限制或由于更具体的营养作用而延长寿命的争论。营养研究的最新进展，尤其是状态空间几何模型几何框架（GF）的开发，为弄清卡路里和营养素的影响提供了新的机会。我们首先介绍这些模型，然后列出建立营养与衰老之间关系必须解决的四个问题，并指出GF如何帮助解决这些问题。接下来，我们提供示例实验协议，并考虑实施GF的一些实际挑战。我们的结论是果蝇为初步研究提供了最合适的系统。

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