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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >A population-based study of hemoglobin, race, and mortality in elderly persons.
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A population-based study of hemoglobin, race, and mortality in elderly persons.

机译：一项基于人群的老年人血红蛋白，种族和死亡率的研究。

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BACKGROUND: Anemia is associated with increased mortality risk. The impact of mildly low hemoglobin concentration (Hb) on risk for mortality remains unclear, especially among blacks. We examined the racial differences between Hb and mortality. METHODS: This was a population-based study conducted from 1993 through 2006, in a geographically defined community of Chicago, Illinois. A stratified, random sample of 1806 participants 65 years old or older and 50% black, who were participating in the Chicago Health Aging Project and underwent clinical evaluation. Mortality was ascertained using the National Death Index. Cox proportional hazard models were used to assess the independent relation of Hb to mortality risk. RESULTS: The proportion of participants with anemia by World Health Organization (WHO) criteria (Hb < 13.0 g/dL for men and < 12.0 g/dL for women) was 39% among blacks, and 17% among whites. Blacks had lower mean Hb (12.6 +/- 1.5 g/dL) than did whites (13.5 +/- 1.5 g/dL). In multivariable analysis, anemia was associated with increased mortality risk in blacks (hazard ratio [HR], 1.90; 95% confidence interval [CI], 1.43-2.53) and in whites (HR, 1.85; 95% CI, 1.32-2.59). Among blacks, Hb 0-0.9 g/dL below the anemia threshold is associated with increased mortality risk compared to Hb 0-0.9 g/dL above the anemia cutoff (HR, 1.84; 95% CI, 1.21-2.79), Hb 1.1-2.0 g/dL above the anemia cutoff (HR, 1.35; 95% CI, 0.88-2.05) and Hb 2.1-3.0 g/dL above the anemia cutoff (HR, 2.24; 95% CI, 1.12-4.47). The terms for interaction between black ethnicity/race and anemia suggested that blacks did not have a statistically significant difference in mortality risk compared to whites. Subgroup analyses of interaction terms suggested that Hb 0.1-1.0 g/dL above anemia cutoff group, blacks may have lower mortality risk compared to whites in the mildly low normal ranges of Hb (p =.02). CONCLUSION: Both anemia by WHO criteria and mild reductions in Hb were related to increased risk of mortality in older blacks and whites.
机译：背景：贫血与死亡风险增加相关。尚低的血红蛋白浓度（Hb）对死亡风险的影响尚不清楚，尤其是在黑人中。我们检查了血红蛋白和死亡率之间的种族差异。方法：这是一项基于人群的研究，从1993年至2006年，在伊利诺伊州芝加哥一个地理上界定的社区中进行。分层，随机抽样的1806名年龄在65岁以上，黑人占50％的参与者参加了芝加哥健康老龄化项目并接受了临床评估。使用国家死亡指数确定死亡率。使用Cox比例风险模型评估Hb与死亡风险的独立关系。结果：按照世界卫生组织（WHO）的标准（男性Hb <13.0 g / dL，女性Hb <12.0 g / dL），贫血参与者的比例在黑人中为39％，在白人中为17％。黑人的平均Hb（12.6 +/- 1.5 g / dL）低于白人（13.5 +/- 1.5 g / dL）。在多变量分析中，贫血与黑人（危险比[HR]，1.90; 95％置信区间[CI]，1.43-2.53）和白人（HR，1.85; 95％CI，1.32-2.59）的死亡风险增加相关。在黑人中，低于贫血阈值的Hb 0-0.9 g / dL与高于贫血临界值的Hb 0-0.9 g / dL（HR，1.84; 95％CI，1.21-2.79），Hb 1.1-高于贫血临界值2.0 g / dL（HR，1.35; 95％CI，0.88-2.05）和Hb高于贫血临界值2.1-3.0 g / dL（HR，2.24; 95％CI，1.12-4.47）。黑人种族/种族与贫血之间的相互作用的术语表明，与白人相比，黑人在死亡风险上没有统计学上的显着差异。相互作用项的亚组分析表明，Hb比贫血临界值组高0.1-1.0 g / dL，在正常的Hb偏低范围内，黑人与白人相比可能具有较低的死亡风险（p = .02）。结论：根据WHO标准的贫血和Hb的轻度降低均与年龄较大的黑人和白人的死亡风险增加有关。

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