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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Diminished acute phase response and increased hepatic inflammation of aged rats in response to intraperitoneal injection of lipopolysaccharide.
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Diminished acute phase response and increased hepatic inflammation of aged rats in response to intraperitoneal injection of lipopolysaccharide.

机译：腹膜内注射脂多糖可减轻老年大鼠的急性期反应，并增加肝脏炎症。

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摘要

Aging is associated with a deterioration of the acute phase response to inflammatory challenges. However, the nature of these defects remains poorly defined. We analyzed the hepatic inflammatory response after intraperitoneal administration of lipopolysaccharide (LPS) given to Fisher 344 rats aged 6, 15, and 22-23 months. Induction of the acute phase proteins (APPs), haptoglobin, alpha-1-acid glycoprotein, and T-kininogen was reduced and/or retarded with aging. Initial induction of interleukin-6 in aged rats was normal, but the later response was increased relative to younger counterparts. An exacerbated hepatic injury was observed in aged rats receiving LPS, as evidenced by the presence of multiple microabscesses in portal tracts, confluent necrosis, higher neutrophil accumulation, and elevated serum levels of alanine aminotransferase, relative to younger animals. Our results suggest that aged rats displayed a reduced expression of APPs and increased hepatic injury in response to the inflammatory insult.
机译：衰老与对炎症挑战的急性期反应恶化有关。但是，这些缺陷的性质仍然定义不清。我们分析了给予6、15和22-23个月大的Fisher 344大鼠腹膜内给予脂多糖（LPS）后的肝炎性反应。随着年龄的增长，急性期蛋白（APPs），触觉珠蛋白，α-1-酸糖蛋白和T激肽原的诱导减少和/或延迟。在老龄大鼠中白细胞介素6的初始诱导是正常的，但是相对于年轻的白细胞，后来的反应增加。相对于年幼的动物，在接受LPS的老龄大鼠中观察到肝损伤加剧，其表现为门静脉道中存在多个微脓肿，融合坏死，中性粒细胞积累增加以及血清丙氨酸转氨酶水平升高。我们的研究结果表明，老年大鼠对炎性损伤的反应显示APP的表达减少，肝损伤增加。

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