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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community.
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Oxidative protein damage is associated with elevated serum interleukin-6 levels among older moderately to severely disabled women living in the community.

机译：氧化蛋白损伤与居住在社区中的中老年至重度残疾妇女的血清白细胞介素6水平升高有关。

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摘要

BACKGROUND: Elevated interleukin (IL)-6 is associated with adverse outcomes. Our objective was to determine whether serum protein carbonyls, an indicator of oxidative protein damage and oxidative stress, were associated with IL-6. METHODS: Serum protein carbonyls and IL-6 were measured in 739 women, age > or 65 years, in the Women's Health and Aging Study I. RESULTS: Geometric mean of protein carbonyls was 0.082 nmol/mg. After adjusting for age and smoking status, log(e) serum protein carbonyls were associated with log(e) IL-6 (beta = 0.143, standard error [SE] = 0.048, p =.003) in linear regression analyses and with elevated IL-6 (> or =2.5 pg/mL) (odds ratio = 1.38, 95% confidence interval, 1.02-1.86, p =.037) in logistic regression analyses. CONCLUSION. Oxidative damage to proteins is independently associated with serum IL-6 among older women living in the community. Increased oxidative stress may be a factor involved in the pathogenesis of the proinflammatory state that occurs in older adults.
机译：背景：白介素（IL）-6升高与不良预后相关。我们的目标是确定血清蛋白羰基是否与IL-6相关，该蛋白是氧化蛋白损伤和氧化应激的指标。方法：在妇女健康与衰老研究I中，对739名年龄≥65岁的女性进行了血清蛋白羰基和IL-6的测定。结果：蛋白羰基的几何平均值为0.082 nmol / mg。在调整了年龄和吸烟状况后，在线性回归分析中log（e）血清蛋白羰基与log（e）IL-6（β= 0.143，标准误[SE] = 0.048，p = .003）相关，且升高logistic回归分析中的IL-6（>或= 2.5 pg / mL）（比值= 1.38，95％置信区间，1.02-1.86，p = .037）。结论。蛋白质的氧化损伤与居住在社区中的老年妇女的血清IL-6独立相关。氧化应激增加可能是老年人发炎状态的发病机制中的一个因素。

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