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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Loss of postprandial insulin sensitization during aging.
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Loss of postprandial insulin sensitization during aging.

机译：衰老过程中餐后胰岛素敏感性下降。

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With aging, there is a decrease in parasympathetic nervous activity. Since the hepatic parasympathetic nerves (HPNs) are essential to the disposal of nutrients, through the hepatic insulin sensitizing substance (HISS), we tested the hypothesis that aging leads to a lowering of postprandial glucose disposal by a decrease of the HISS-dependent component of insulin action. Insulin sensitivity was quantified in fed or fasted, male and female Wistar rats (from 6 to 52 weeks), using a euglycemic clamp. The HISS-dependent component was quantified by administration of the muscarinic antagonist atropine. Total insulin action decreased gradually up to 52 weeks of age: The HISS-independent component of insulin action decreased until 9 weeks of age and remained unchanged thereafter; the HISS-dependent component decreased from 9 weeks of age throughout aging. The continuous decrease of HISS action, uncovered by blocking the HPN, is the key phenomenon for the gradual decrease of insulin sensitivity with aging.
机译：随着年龄的增长，副交感神经活动减少。由于肝副交感神经（HPNs）对于营养的处置至关重要，因此我们通过肝胰岛素敏化物质（HISS）检验了以下假设：衰老可通过减少HISS依赖性成分而导致餐后葡萄糖处置降低胰岛素作用。使用正常血糖钳，在进食或禁食的雄性和雌性Wistar大鼠（6至52周）中量化胰岛素敏感性。通过施用毒蕈碱拮抗剂阿托品来定量HISS依赖性成分。直至52周龄，总胰岛素作用逐渐降低：胰岛素作用的HISS独立成分下降至9周龄，此后保持不变。在整个衰老过程中，依赖于HISS的成分从9周龄开始下降。通过阻断HPN可以发现HISS作用的持续降低是随着年龄增长胰岛素敏感性逐渐降低的关键现象。

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