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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Patient age influences recognition of Alzheimer's disease.
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Patient age influences recognition of Alzheimer's disease.

机译：患者年龄影响阿尔茨海默氏病的识别。

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Background. This study evaluated whether patient age influences recognition of Alzheimer's disease (AD) as assessed by referrals to a specialty clinic. Methods. The age and Mini-Mental State Exam (MMSE) at the initial visit to a memory loss clinic of all patients with a diagnosis of AD (n = 533; 88.7%) or amnestic Mild Cognitive Impairment (n = 68; 11.3%) seen from 1992 through 2004 were examined. Only patients seen at least twice were considered so that the potentially confounding effects of age on rate of decline could be examined. Results. There was a significant inverse correlation between age and MMSE score at initial visit (Spearman rho = -0.10, p =.016). Mixed-model regression analyses revealed significant effects of age and calendar year at initial visit on initial MMSE score and estimated the annual rate of decline on the MMSE at 1.58 points per year. Age at initial visit was not related to the rate of MMSE decline over time. Conclusions. Recognition of symptoms of AD is delayed as patients age. This delay is not explained by a difference in the rate of decline with age. Even though AD incidence increases dramatically with age, older patients were found to be more advanced in their disease at the time of referral to a dementia clinic.
机译：背景。这项研究评估了患者的年龄是否会影响转诊至专科诊所评估的阿尔茨海默氏病（AD）。方法。首次就诊于所有患有AD（n = 533; 88.7％）或遗忘性轻度认知障碍（n = 68; 11.3％）的患者的记忆丧失诊所就诊时的年龄和小精神状态检查（MMSE）从1992年到2004年进行了检查。仅考虑至少看过两次的患者，以便可以检查年龄对下降率的潜在混杂影响。结果。在初次就诊时，年龄与MMSE评分之间存在显着的负相关（Spearman rho = -0.10，p = .016）。混合模型回归分析显示，初访时的年龄和日历年对MMSE初始得分有显着影响，并且MMSE的年下降率估计为每年1.58分。初诊时的年龄与MMSE随时间下降的速度无关。结论。随着年龄的增长，AD症状的识别被延迟。这种延迟不能通过年龄下降率的差异来解释。即使AD发病率随着年龄的增长而急剧增加，但在转诊至痴呆症诊所时，发现老年患者的病情更为严重。

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