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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age-related deficit in load-induced skeletal muscle growth.
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Age-related deficit in load-induced skeletal muscle growth.

机译：负荷引起的骨骼肌生长中与年龄有关的缺陷。

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The growth response of ankle flexor and extensor muscles to two models of increased loading, functional overload (FO) and hind-limb reloading following hind-limb suspension, was measured by wet weight in Fisher 344-Brown Norway rats at ages ranging from 6 to 30 months. In response to FO, there was a 40% decrease in absolute growth of the plantaris beginning in middle age. Interestingly, the growth response to FO of 30-month old rats maintained on a 40% calorie-restricted diet improved by more than twofold relative to 30-month old rats on a normal chow diet. Recovery of muscle mass upon reloading following disuse was significantly impaired (reduced 7-16%) in predominantly fast, but not slow, muscles of 30-month relative to 9-month old rats. Initial investigation of the Akt signaling pathway following FO suggests a reduction or delay in activation of Akt and its downstream targets in response to increased loading in old rats.
机译：在Fisher 344-Brown Norway大鼠中，通过湿重测量6岁至6岁之间的湿重，测量踝关节屈肌和伸肌对两种增加负荷的模型的反应，其中功能性负荷（FO）和后肢再加载后肢再加载。 30个月对FO的反应是，从中年开始the骨的绝对生长减少了40％。有趣的是，相对于正常饮食的30个月大大鼠，维持40％热量限制饮食的30个月大的大鼠对FO的生长反应提高了两倍以上。相对于9个月大的大鼠，在30个月的快速但不缓慢的肌肉中，停用后重装后肌肉质量的恢复显着受损（降低了7-16％）。 FO后对Akt信号通路的初步研究表明，响应于老龄大鼠负荷增加，Akt及其下游靶标的激活减少或延迟。

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