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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Is older colder or colder older? The association of age with body temperature in 18,630 individuals.
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Is older colder or colder older? The association of age with body temperature in 18,630 individuals.

机译：是更冷还是更冷？ 18,630人中年龄与体温的关系。

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摘要

In animal studies, caloric restriction resulting in increased longevity is associated with a reduction in body temperature, which is strain specific and likely under genetic control. Small studies in humans have suggested that temperatures may be lower among elderly populations, usually attributed to loss of thermoregulation. We analyzed cross-sectional data from 18,630 white adults aged 20-98 years (mean 58.3 years) who underwent oral temperature measurement as part of a standardized health appraisal at a large U.S. health maintenance organization. Overall, women had higher mean temperatures (97.5 +/- 1.2 degrees F) than men (97.2 +/- 1.1 degrees F; p < .0001). Mean temperature decreased with age, with a difference of 0.3 degrees F between oldest and youngest groups after controlling for sex, body mass index, and white blood cell count. The results are consistent with low body temperature as a biomarker for longevity. Prospective studies are needed to confirm whether this represents a survival advantage associated with lifetime low steady state temperature.
机译：在动物研究中，热量限制导致寿命增加与体温降低有关，体温降低是菌株特异性的，并且可能在遗传控制下。对人类的小型研究表明，老年人群中的温度可能较低，这通常归因于体温调节的丧失。我们分析了18630名20-98岁（平均58.3岁）的白人成年人的横断面数据，这些成年人接受了口腔温度测量，这是美国大型健康维护组织进行的标准化健康评估的一部分。总体而言，女性的平均温度（97.5 +/- 1.2华氏度）高于男性（97.2 +/- 1.1华氏度; p <.0001）。平均温度随着年龄的增长而下降，在控制性别，体重指数和白细胞计数之后，最老和最年轻的群体之间的平均气温差为0.3华氏度。结果与低体温作为长寿的生物标志物是一致的。需要进行前瞻性研究，以确认这是否代表与寿命低稳态温度相关的生存优势。

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