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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement.
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Megestrol acetate-induced weight gain does not negatively affect blood lipids in elderly men: effects of resistance training and testosterone replacement.

机译：醋酸孕甾酮引起的体重增加不会对老年男性的血脂产生负面影响：抵抗力训练和睾丸激素替代的影响。

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BACKGROUND: Megestrol acetate (MA) has been used to stimulate weight gain in elderly populations, with the majority of the weight gain being adipose tissue. Because of the increased energy intake and adipose tissue accrual with MA, it may have a negative effect on circulating lipids. Thus, in this study we examined the effects of MA--alone and in combination with resistance training and/or testosterone replacement--on blood lipids. METHODS: All subjects (n = 28) received MA and were randomly assigned to one of four groups: 1) placebo (P) injections, 2) resistance training and P (RT+P), 3) weekly injections of testosterone (T; 100 mg/week), or 4) RT and T (RT+T). RESULTS: A significant time effect was observed for total cholesterol (p = 0.0006) and high density lipoprotein (HDL) cholesterol (p .0003) with the mid and post time points being significantly lower than the pre time points for both variables. For the total cholesterol to HDL ratio, no significant differences between groups or over time (time effect: ) were observed. For triglycerides, there tended to be a time effect (p = .061), with the mid and post time points being lower than the pre time point; however, this effect was not statistically significant. CONCLUSIONS: Because it appears from our data that MA does not cause adverse blood lipid changes, the decision to use it should be based on other factors.
机译：背景：醋酸孕甾酮（MA）已被用于刺激老年人群的体重增加，其中大部分体重增加是脂肪组织。由于MA摄入的能量增加和脂肪组织增加，因此可能对循环脂质产生负面影响。因此，在这项研究中，我们研究了单抗或与抗性训练和/或睾丸激素替代相结合的MA对血脂的影响。方法：所有受试者（n = 28）均接受MA，并随机分为四组之一：1）安慰剂（P）注射; 2）抵抗力训练和P（RT + P）; 3）每周注射睾丸激素（T; 4）。 100 mg /周），或4）RT和T（RT + T）。结果：总胆固醇（p = 0.0006）和高密度脂蛋白（HDL）胆固醇（p .0003）的时间效应显着，两个变量的中，后时间点均显着低于预时间点。对于总胆固醇与HDL的比率，两组之间或随着时间的推移均未观察到显着差异（时间效应：）。对于甘油三酸酯，往往会产生时间效应（p = .061），而中点和后点的时间点要比前点的时间点低;但是，这种影响在统计上并不显着。结论：由于从我们的数据看来，MA不会引起不利的血脂变化，因此应基于其他因素决定使用它。

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