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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis.
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Insulin resistance, affective disorders, and Alzheimer's disease: review and hypothesis.

机译：胰岛素抵抗，情感障碍和阿尔茨海默氏病：回顾和假设。

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摘要

Affective disorders (ad) and Alzheimer's disease (AD) have been associated for almost a century, and various neurophysiologic factors have been implicated as common biologic markers. Yet, links between ad and AD still await elucidation. We propose that insulin resistance (IR) is one of the missing links between ad and AD. IR with hyperinsulinemia and subsequent impairment of glucose metabolism especially in ad patients may promote neurodegeneration and facilitate the onset of AD. According to our hypothesis, IR may persist even into ad remission in some patients. Persistent regional hypometabolism and vascular changes resulting from long-standing IR may lead to currently irreversible structural changes. Evidence in support of the hypothesis is reviewed and clinical implications suggested.
机译：情感障碍（ad）和阿尔茨海默氏病（AD）已有近一个世纪的历史了，各种神经生理因素被认为是常见的生物学标记。然而，广告和广告之间的联系仍在等待阐明。我们建议胰岛素抵抗（IR）是ad和AD之间缺少的环节之一。 IR伴有高胰岛素血症和随后的糖代谢受损，尤其是在ad患者中，可能促进神经退行性变并促进AD的发作。根据我们的假设，某些患者的IR甚至可以持续到广告缓解。长期的IR引起的持续性区域低代谢和血管变化可能导致当前不可逆的结构变化。审查支持该假设的证据，并提出临床意义。

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