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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Correlations with longevity and body size: To correct or not correct?
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Correlations with longevity and body size: To correct or not correct?

机译：与寿命和体型的关系：矫正还是不矫正？

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I recently read the article by Csiszar and colleagues (1). They show for the first time, in fibroblasts from 13 primate species including anthropoids and humans, that the mean level of reactive oxygen species (ROS) is low in long-lived compared with short-lived animals. Their measurements are not "ROS production" because they were performed in whole cells, and thus cellular antioxidants interfere. But the negative correlation between mitochondrial ROS production (mtROSp) and longevity observed in many studies in mammals and birds (2) prevailed even with interference from cellular antioxidants. Long-lived animals have less endogenous antioxidants (3-5) and less mtROSp (2) than short-lived ones. Therefore, in whole cells, both factors would tend to cancel each other, but still the low mtROSp of the long-lived species seems to have predominated in this case.
机译：我最近阅读了Csiszar及其同事的文章（1）。它们首次显示，在13种灵长类动物的成纤维细胞中，包括人猿和人类在内，与短命动物相比，长寿动物的平均活性氧（ROS）水平较低。他们的测量结果不是“ ROS产生”，因为它们是在完整细胞中进行的，因此细胞抗氧化剂会干扰。但是，即使受到细胞抗氧化剂的干扰，在哺乳动物和鸟类的许多研究中，线粒体ROS产量（mtROSp）与寿命之间也存在负相关关系（2）。长寿动物比短寿动物具有更少的内源性抗氧化剂（3-5）和更少的mtROSp（2）。因此，在整个细胞中，这两个因素趋向于相互抵消，但在这种情况下，长寿命物种的低mtROSp似乎仍然占主导地位。

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