...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Evidence for less marked potential signs of T-cell immunosenescence in centenarian offspring than in the general age-matched population
【24h】

Evidence for less marked potential signs of T-cell immunosenescence in centenarian offspring than in the general age-matched population

机译：百岁老人后代中T细胞免疫衰老的潜在迹象较普通年龄匹配人群的证据少

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

People may reach the upper limits of the human life span at least partly because they have maintained more appropriate immune function, avoiding changes to immunity termed "immunosenescence." Exceptionally long-lived people may be enriched for genes that contribute to their longevity, some of which may bear on immune function. Centenarian offspring would be expected to inherit some of these, which might be reflected in their resistance to immunosenescence, and contribute to their potential longevity. We have tested this hypothesis by comparing centenarian offspring with age-matched controls. We report differences in the numbers and proportions of both CD4+ and CD8+ early- and late-differentiated T cells, as well as potentially senescent CD8+ T cells, suggesting that the adaptive T-cell arm of the immune system is more "youthful" in centenarian offspring than controls. This might reflect a superior ability to mount effective responses against newly encountered antigens and thus contribute to better protection against infection and to greater longevity.
机译：人们之所以可以达到人类寿命的上限，至少部分原因是因为他们保持了更适当的免疫功能，避免了被称为“免疫衰老”的免疫力的改变。长寿的人可能会丰富有助于长寿的基因，其中一些可能会影响免疫功能。百岁后代有望继承其中的一些，这可能反映在它们对免疫衰老的抵抗力中，并有助于其长寿。我们通过将百岁老人的后代与年龄匹配的对照进行比较，检验了这一假设。我们报告了CD4 +和CD8 +早期和晚期分化的T细胞以及潜在衰老的CD8 + T细胞的数量和比例的差异，表明免疫系统的适应性T细胞臂在百岁老人中更“年轻”后代比对照。这可能反映出对新近遇到的抗原产生有效应答的卓越能力，从而有助于更好地防止感染并延长寿命。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号