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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) sarcopenia project
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Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) sarcopenia project

机译：临床上相关的虚弱和低体重的标准及其与意外移动性损害和死亡率的纵向关联：美国国立卫生研究院（FNIH）肌肉减少症项目

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Background.This analysis sought to determine the associations of the Foundation for the National Institutes of Health Sarcopenia Project criteria for weakness and low lean mass with likelihood for mobility impairment (gait speed ≤ 0.8 m/s) and mortality. Providing validity for these criteria is essential for research and clinical evaluation.Methods.Among 4,411 men and 1,869 women pooled from 6 cohort studies, 3-year likelihood for incident mobility impairment and mortality over 10 years were determined for individuals with weakness, low lean mass, and for those having both. Weakness was defined as low grip strength (26kg men and 16kg women) and low grip strength-to-body mass index (BMI; kg/m2) ratio (1.00 men and 0.56 women). Low lean mass (dual-energy x-ray absorptiometry) was categorized as low appendicular lean mass (ALM; 19.75kg men and 15.02kg women) and low ALM-to-BMI ratio (0.789 men and 0.512 women).Results.Low grip strength (men: odds ratio [OR] = 2.31, 95% confidence interval [CI] = 1.34-3.99; women: OR = 1.99, 95% CI 1.23-3.21), low grip strength-to-BMI ratio (men: OR = 3.28, 95% CI 1.92-5.59; women: OR = 2.54, 95% CI 1.10-5.83) and low ALM-to-BMI ratio (men: OR = 1.58, 95% CI 1.12-2.25; women: OR = 1.81, 95% CI 1.14-2.87), but not low ALM, were associated with increased likelihood for incident mobility impairment. Weakness increased likelihood of mobility impairment regardless of low lean mass. Mortality risk patterns were inconsistent.Conclusions.These findings support our cut-points for low grip strength and low ALM-to-BMI ratio as candidate criteria for clinically relevant weakness and low lean mass. Further validation in other populations and for alternate relevant outcomes is needed.
机译：背景：这项分析试图确定美国国立卫生研究院肌少症项目基金会针对虚弱和低体重的标准与行动障碍（步态速度≤0.8 m / s）和死亡率的关联。方法：从6项队列研究中收集了4,411名男性和1,869名女性的研究，确定了虚弱，低瘦体重人群的3年发生活动性障碍和死亡率超过10年的可能性，以及同时拥有两者的用户。弱点定义为低握力（男性<26kg，女性<16kg）和低握力与身体质量指数（BMI; kg / m2）之比（男性<1.00，女性<0.56）。低瘦体重（双能X线骨密度仪）被归类为低阑尾瘦体重（ALM;男性<19.75kg，女性<15.02kg）和ALM与BMI的比率低（男性<0.789，女性<0.512）。结果：抓地力低（男子：优势比[OR] = 2.31，95％置信区间[CI] = 1.34-3.99;女子：OR = 1.99，95％CI 1.23-3.21），抓地力与BMI比率低（男性：OR = 3.28，95％CI 1.92-5.59;女性：OR = 2.54，95％CI 1.10-5.83）和低ALM与BMI的比率（男性：OR = 1.58，95％CI 1.12-2.25;女性：或= 1.81，95％CI 1.14-2.87），但ALM值不低，与事件迁移率受损的可能性增加有关。弱势增加了运动能力损害的可能性，而与低瘦体重无关。死亡率风险模式不一致。结论：这些发现支持我们将低握力和低ALM / BMI比作为临床相关虚弱和低瘦体重的候选标准。需要在其他人群中进行进一步验证，并获得其他相关结果。

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