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The 'Cytokine for Gerontologists' Has Some Company

机译:“老年医学的细胞因子”有一些陪伴

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摘要

FRAILTY has long been recognized as a complex syndrome of failure to thrive in the elderly adults. When Fried and colleagues (1) suggested the first comprehensive definition for frailty, they helped set in motion many studies of this complex condition; three more of these are published in this edition of the Journal. Even earlier, Rosenberg (2) had proposed sarcopenia as a term to describe the loss of muscle with normal aging, in parallel with osteopenia, and had suggested that sarcopenia was an important part of the pathophysiology of aging and frailty. The link between sarcopenia, frailty, and inflammation has beguiled researchers for decades, and remains central to our understanding of the pathophysiology of age-related decline in function.
机译:长期以来,脆弱一直被认为是老年人无法failure壮成长的复杂综合症。当Fried和同事(1)提出了关于脆弱的第一个综合定义时,他们帮助推动了许多有关这种复杂状况的研究。其中三本在本期《期刊》上发表。甚至在更早的时候,Rosenberg(2)提出了少肌症这个名词来描述正常衰老与骨质减少有关的肌肉损失,并暗示少肌症是衰老和虚弱的病理生理学的重要组成部分。肌肉减少症,虚弱和炎症之间的联系已经困扰着研究人员数十年,并且仍然是我们对与年龄相关的功能下降的病理生理学理解的核心。

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