P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

Waaijer Mariette E. C.; Gunn David A.; Adams Peter D.; Pawlikowski Jeff S.; Griffiths Christopher E. M.; van Heemst Diana; Slagboom P. Eline; Westendorp Rudi G. J.; Maier Andrea B.

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P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

机译：人皮肤中的P16INK4a阳性细胞指示局部弹性纤维形态，面部皱纹和感知年龄

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The numbers of epidermal and dermal p16INK4a positive cells were significantly associated with age-associated elastic fiber morphologic characteristics, such as longer and a greater number of elastic fibers. The p16INK4a positive epidermal cells (identified as primarily melanocytes) were also significantly associated with more facial wrinkles and a higher perceived age. Participants in the lowest tertile of epidermal p16INK4a counts looked 3 years younger than those in the highest tertile, independently of chronological age and elastic fiber morphology.

机译：表皮和真皮p16INK4a阳性细胞的数量与与年龄相关的弹性纤维形态特征显着相关，例如更长和更多数量的弹性纤维。 p16INK4a阳性表皮细胞（主要被识别为黑素细胞）也与更多的面部皱纹和更高的感知年龄显着相关。表皮p16INK4a计数最低三分位数的参与者比年龄最高三分位数的参与者年轻3岁，而不受年代年龄和弹性纤维形态的影响。

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《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2016年第8期|共7页
作者
Waaijer Mariette E. C.; Gunn David A.; Adams Peter D.; Pawlikowski Jeff S.; Griffiths Christopher E. M.; van Heemst Diana; Slagboom P. Eline; Westendorp Rudi G. J.; Maier Andrea B.;
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正文语种 eng
中图分类老年病学;
关键词
p16INK4a; Cell senescence; Skin; Wrinkle; Elastic fiber;

机译：p16INK4a;细胞衰老;皮肤;皱纹;弹性纤维;

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1. P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age [J] . Waaijer Mariette E. C., Gunn David A., Adams Peter D., The journals of gerontology.Series A. Biological sciences and medical sciences . 2016,第8期

机译：人皮肤中的P16INK4a阳性细胞指示局部弹性纤维形态，面部皱纹和感知年龄
2. The number of p16INK4a positive cells in human skin reflects biological age [J] . WaaijerM.E., ParishW.E., StrongitharmB.H., Aging cell. . 2012,第4期

机译：人皮肤中p16INK4a阳性细胞的数量反映了生物学年龄
3. The number of p16INK4a positive cells in human skin reflects biological age [J] . Anton J.M. de Craen, Barbara H. Strongitharm, David A. Gunn, Aging cell. . 2012,第4期

机译：人皮肤中p16INK4a阳性细胞的数量反映了生物学年龄
4. Automated localization of wrinkles and the dermo-epidermal junction in obliquely-oriented reflectance confocal microscopic images of human skin [C] . Jamshid Sourati, Kivanc Kose, Milind Rajadhyaksha, Conference on photonic therapeutics and diagnostics IX . 2013

机译：人皮肤倾斜定向反射共聚焦显微图像中皱纹和皮肤-表皮交界的自动定位
5. Expression and Localization Dynamics of The Aging Biomarker P16INK4a in Response to Cellular Stress, Autophagy, and Epigenetic Modulators [D] . Coryell, Philip Richard. 2019

机译：老化生物标志物P16ink4a响应细胞应激，自噬和表观遗传调节剂的表达和定位动态
6. P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology Facial Wrinkling and Perceived Age [O] . Mariëtte E. C. Waaijer, David A. Gunn, Peter D. Adams, -1

机译：人皮肤中的P16INK4a阳性细胞指示局部弹性纤维形态面部皱纹和感知年龄
7. P16INK4a positive cells in human skin are indicative of local elastic fiber morphology, facial wrinkling, and perceived age [O] . Waaijer Mariëtte E.C., Gunn David A., Adams Peter D., 2016

机译：人皮肤中的p16INK4a阳性细胞表明局部弹性纤维形态，面部皱纹和感知年龄

P16INK4a Positive Cells in Human Skin Are Indicative of Local Elastic Fiber Morphology, Facial Wrinkling, and Perceived Age

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