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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence.
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Cholinergic deficiency hypothesis in delirium: a synthesis of current evidence.

机译：ir妄的胆碱能缺乏假说：现有证据的综合。

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Deficits in cholinergic function have been postulated to cause delirium and cognitive decline. This review examines current understanding of the cholinergic deficiency hypothesis in delirium by synthesizing evidence on potential pathophysiological pathways. Acetylcholine synthesis involves various precursors, enzymes, and receptors, and dysfunction in these components can lead to delirium. Insults to the brain, like ischemia and immunological stressors, can precipitously alter acetylcholine levels. Imbalances between cholinergic and other neurotransmitter pathways may result in delirium. Furthermore, genetic, enzymatic, and immunological overlaps exist between delirium and dementia related to the cholinergic pathway. Important areas for future research include identifying biomarkers, determining genetic contributions, and evaluating response to cholinergic drugs in delirium. Understanding how the cholinergic pathway relates to delirium may yield innovative approaches in the diagnosis, prevention, and treatment of this common, costly, and morbid condition.
机译：胆碱能功能的不足被认为会引起del妄和认知能力下降。这篇综述通过综合关于潜在病理生理途径的证据，检验了current妄中胆碱能缺乏假说的当前理解。乙酰胆碱合成涉及各种前体，酶和受体，这些成分的功能障碍会导致lead妄。像缺血和免疫应激一样，对大脑的伤害会急剧改变乙酰胆碱的水平。胆碱能和其他神经递质途径之间的失衡可能导致result妄。此外，与胆碱能途径有关的genetic妄和痴呆之间存在遗传，酶和免疫学重叠。未来研究的重要领域包括鉴定生物标记，确定遗传贡献以及评估evaluating妄对胆碱能药物的反应。了解胆碱能途径与del妄的关系可能会为这种常见的，昂贵的和病态的疾病的诊断，预防和治疗提供创新的方法。

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