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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people.
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The developmental origins of sarcopenia: using peripheral quantitative computed tomography to assess muscle size in older people.

机译：肌肉减少症的发展起源：使用外周定量计算机体层摄影术评估老年人的肌肉大小。

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BACKGROUND: A number of studies have shown strong graded positive relationships between size at birth, grip strength, and estimates of muscle mass in older people. However no studies to date have included direct measures of muscle size. METHODS: We studied 313 men and 318 women born in Hertfordshire, United Kingdom between 1931 and 1939 who were still resident there and had historical records of growth in early life. Information on lifestyle was collected, and participants underwent peripheral quantitative computed tomography to directly measure forearm and calf muscle size. RESULTS: Birth weight was positively related to forearm muscle area in the men (r = 0.24, p <.0001) and women (r = 0.17, p =.003). There were similar but weaker associations between birth weight and calf muscle area in the men (r = 0.13, p =.03) and in the women (r = 0.17, p =.004). These relationships were all attenuated by adjustment for adult size. CONCLUSION: We present first evidence that directly measured muscle size in older men and women is associated with size at birth. This may reflect tracking of muscle size and is important because it suggests that benefit may be gained from taking a life course approach both to understanding the etiology of sarcopenia and to developing effective interventions.
机译：背景：许多研究表明，出生时的大小，握力和老年人的肌肉质量之间存在强烈的正相关关系。然而，迄今为止尚无研究包括对肌肉大小的直接测量。方法：我们研究了1931年至1939年间在英国赫特福德郡出生的313名男性和318名女性，这些人仍然居住在英国，并有早期成长的历史记录。收集有关生活方式的信息，并对参与者进行外周定量计算机体层摄影术以直接测量前臂和小腿肌肉的大小。结果：出生体重与男性（r = 0.24，p <.0001）和女性（r = 0.17，p = .003）前臂肌肉面积呈正相关。男性（r = 0.13，p = .03）和女性（r = 0.17，p = .004）的出生体重和小腿肌肉面积之间存在相似但较弱的关联。通过调整成人大小，这些关系都被削弱了。结论：我们提供了第一个证据，即直接测量老年男性和女性的肌肉大小与出生时的大小有关。这可能反映了对肌肉大小的跟踪，这一点很重要，因为它表明，采用生命过程方法来了解肌肉减少症的病因并制定有效的干预措施可能会受益。

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