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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung.
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Airspace enlargement with airway cell apoptosis in klotho mice: a model of aging lung.

机译：klotho小鼠气道细胞凋亡的空域扩大：肺衰老的模型。

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摘要

Homozygous mutant klotho (KL(-/-)) mice exhibit various characteristics resembling those of human aging, including emphysema. However, age-related changes of lungs have not been fully elucidated. Here, we investigated the structural, functional, biochemical, and cell kinetic alterations of lungs in KL(-/-) mice at 2-12 weeks of age. Homogeneous airspace enlargement and decreased lung elastic recoil were observed in KL(-/-) mice with aging. The apoptotic cells in airway walls in KL(-/-) mice were approximately 6 times greater than those in wild-type (KL(+/+)) mice at 2 weeks of age. However, lipid peroxidation and elastase activity of lungs were not increased in KL(-/-) mice. Western blotting suggested that protein levels of epidermal growth factor (EGF) and phosphorylated extracellular signal-regulated kinase were decreased in KL(-/-) mice. These data suggest that significantly increased apoptosis of airway cells via inhibition of the EGF-dependent pathway may be involved in the development of the aging lungs in KL(-/-) mice.
机译：纯合突变klotho（KL（-/-））小鼠表现出类似于人类衰老的各种特征，包括肺气肿。但是，尚未完全阐明与年龄相关的肺部变化。在这里，我们调查了2-12周龄的KL（-/-）小鼠中肺的结构，功能，生化和细胞动力学变化。在衰老的KL（-/-）小鼠中观察到同质空域增大和肺弹性后坐力降低。在2周龄时，KL（-/-）小鼠气道壁中的凋亡细胞大约是野生型（KL（+ / +））小鼠中的细胞凋亡细胞的6倍。但是，KL（-/-）小鼠的肺脂质过氧化和弹性蛋白酶活性没有增加。 Western印迹表明，KL（-/-）小鼠的表皮生长因子（EGF）和磷酸化的细胞外信号调节激酶的蛋白水平降低了。这些数据表明通过抑制EGF依赖性途径显着增加气道细胞凋亡可能与KL（-/-）小鼠衰老的肺部发育有关。

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