...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging.
【24h】

Serum Sex Hormones, IGF-1, and IGFBP3 Exert a Sexually Dimorphic Effect on Lean Body Mass in Aging.

机译：血清性激素，IGF-1和IGFBP3对衰老的瘦体重有性二态作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Endogenous and exogenous sex hormones affect changes in body composition during aging via independent and dependent effects on the growth hormone/insulin-like growth factor-1 (GH/IGF-1) axis and associated binding proteins (BP). METHODS: Fasting serum IGF-1, IGFBP3, testosterone, estrone, and sex hormone binding globulin were analyzed in 48 women on hormone replacement (HRT) (unopposed oral estrogen, HRT+, 74.0 +/- 6 years), 135 women not on HRT (HRT-, 77.3 +/- 7 years), and 128 healthy men (men, ). Total lean body mass (LBM) and total fat were measured by dual energy X-ray absorptiometry. RESULTS: Total LBM decreased with age in all groups (p = .05). LBM was greater, and IGF-1, IGFBP3, and testosterone were lower in HRT+ versus HRT- women (p = .02, p = .01, p = .04, and, respectively). LBM in men was positively related to IGF-1 (p = .02) and testosterone (p < .01), whereas LBM was associated with IGFBP3 (p = .04) and total fat (p < .001) in female HRT+ and total fat (p < .01) in HRT- women. IGF-1 decreased with age in men and HRT- women (p < .01) but did not decrease in HRT+ women. Total fat significantly decreased across age (p < .05). Controlling for age and HRT, the rate of decrease in fat was slower in men versus women (p = .02). IGFBP3 decreased in all groups across age (p < .01), and the ratio of IGF-1 to IGFBP3 decreased faster in men compared to HRT+ and HRT- women (p = .02). CONCLUSIONS: Our data indicate divergent influences of sex steroids, IGF-1, and IGFBP3 on age-related changes in LBM in healthy elderly men and women.
机译：背景：内源性和外源性激素通过对生长激素/胰岛素样生长因子-1（GH / IGF-1）轴和相关结合蛋白（BP）的独立和依赖性作用，影响衰老过程中人体成分的变化。方法：对48位接受激素替代（HRT）的女性（口服雌激素，HRT +，74.0 +/- 6岁），未接受HRT的135位女性的空腹血清IGF-1，IGFBP3，睾丸激素，雌酮和性激素结合球蛋白进行了分析。 （HRT-，77.3 +/- 7岁）和128位健康的男性（男性）。通过双能量X射线吸收法测量总瘦体重（LBM）和总脂肪。结果：所有组的总LBM均随年龄而降低（p = .05）。与HRT-女性相比，HRT +中的LBM较大，而IGF-1，IGFBP3和睾丸激素则较低（分别为p = .02，p = .01，p = .04和）。男性的LBM与女性HRT +和IGF-1（p = .02）和睾丸激素（p <.01）正相关，而LBM与IGFBP3（p = .04）和总脂肪（p <.001）相关。女性HRT中的总脂肪（p <.01）。男性和HRT-女性的IGF-1随年龄下降（p <.01），而HRT +女性的IGF-1并未下降。随着年龄的增长，总脂肪显着下降（p <.05）。在控制年龄和HRT的情况下，男性和女性的脂肪减少速率较慢（p = .02）。与HRT +和HRT-女性相比，男性中IGFBP3在所有年龄段中均下降（p <.01），并且男性中IGF-1与IGFBP3的比率下降更快（p = .02）。结论：我们的数据表明，性类固醇，IGF-1和IGFBP3对健康老年男性和女性随年龄变化的LBM变化的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号