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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status.
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Oral testosterone supplementation increases muscle and decreases fat mass in healthy elderly males with low-normal gonadal status.

机译：口服睾丸激素补充剂可增加具有正常性腺状态低下的健康老年男性的肌肉，并减少其脂肪量。

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BACKGROUND: Loss of muscle mass (sarcopenia) leads to frailty in older men. The decline in testosterone over the life span may contribute to this muscle loss. We studied the ability of oral testosterone to prevent muscle loss in older men over a 12-month period. METHODS: A standard dose (80 mg twice daily) of testosterone undecanoate or placebo was administered for 1 year to 76 healthy men aged 60 years or older. All men had a free testosterone index of 0.3-0.5, which represents a value below the normal lower limit for young men (19-30 years), but remains within the overall normal male range. Measurements of body composition, muscle strength, hormones, and safety parameters were obtained at 0, 6, and 12 months. RESULTS: Lean body mass increased (p =.0001) and fat mass decreased (p .02) in the testosterone as compared with the placebo-treated group. There were no significant effects on muscle strength. There was a significant increase in hematocrit (0.02%) in the testosterone-treated group (p =.03). Plasma triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels were similar in both groups, but there was a decrease in high-density lipoprotein cholesterol (-0.1 mmol/L) at 12 months in the testosterone group as compared to the placebo group (p = 0.026). There were no differences in prostate-specific antigen or systolic or diastolic blood pressure between the groups. CONCLUSION: Oral testosterone administration to older relatively hypogonadal men results in an increase in muscle mass and a decrease in body fat.
机译：背景：肌肉质量下降（肌肉减少症）会导致年老体弱的人。整个生命周期中睾丸激素的下降可能导致这种肌肉损失。我们研究了口服睾丸激素在12个月内预防老年男性肌肉丢失的能力。方法：对76名60岁以上的健康男性服用标准剂量的十一酸睾丸激素或安慰剂80毫克，每天两次。所有男性的游离睾丸激素指数为0.3-0.5，该数值低于年轻男性的正常下限（19-30岁），但仍在总体正常男性范围内。在0、6和12个月时获得了人体成分，肌肉力量，激素和安全性参数的测量值。结果：与安慰剂治疗组相比，睾丸激素瘦体重增加（p = .0001），脂肪减少（p .02）。对肌肉力量没有明显影响。睾丸激素治疗组的血细胞比容显着增加（0.02％）（p = .03）。两组的血浆甘油三酸酯，总胆固醇和低密度脂蛋白胆固醇水平相似，但与安慰剂组相比，睾丸激素组在12个月时高密度脂蛋白胆固醇（-0.1 mmol / L）降低（p ＝ 0.026）。两组之间的前列腺特异性抗原或收缩压或舒张压没有差异。结论：对性腺功能减退的老年男性口服睾丸激素可导致肌肉质量增加和体内脂肪减少。

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