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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Aging-associated changes in physical performance and energy metabolism in the senescence-accelerated mouse.
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Aging-associated changes in physical performance and energy metabolism in the senescence-accelerated mouse.

机译：衰老加速小鼠的身体行为和能量代谢的衰老相关变化。

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摘要

The aim of the study was to clarify the aging-associated changes in physical performance and energy metabolism in senescence-accelerated prone mouse (SAMP1). The endurance of aged SAMP1 was significantly lower by 28% than the age-matched senescence-resistant mouse (SAMR1). Oxygen consumption and fat oxidation in aged SAMP1 were lower by 19% and 22%, respectively. Peroxisome proliferator-activated receptor-gamma coactivator-1beta and medium-chain acyl coenzyme A dehydrogenase messenger RNA expression was significantly lower in aged SAMP1. Aged SAMP1 exhibited higher plasma glucose, insulin, leptin, and lower adiponectin concentrations. Aged SAMP1 also had higher malondialdehyde levels in plasma and tissues and lower peroxisome proliferator-activated receptor-gamma messenger RNA and protein levels in adipose tissue. These results indicate that physical performance and energy expenditure decrease earlier with aging in SAMP1, accompanied by decreased fatty acid catabolism in muscle and liver and increased inflammation and oxidative stress in adipose tissue. SAMP1 could thus be a useful accelerated functional depression model for studying physical performance and energy metabolism.
机译：该研究的目的是阐明衰老加速俯卧小鼠（SAMP1）的物理性能和能量代谢与衰老相关的变化。与年龄相匹配的抗衰老小鼠（SAMR1）相比，老年SAMP1的耐受力显着降低了28％。老化的SAMP1的耗氧量和脂肪氧化分别降低了19％和22％。过氧化物酶体增殖物激活的受体-γcoactivator-1beta和中链酰基辅酶A脱氢酶信使RNA表达明显低于老年SAMP1。老化的SAMP1表现出较高的血浆葡萄糖，胰岛素，瘦素和较低的脂联素浓度。老化的SAMP1在血浆和组织中的丙二醛水平也较高，而在脂肪组织中的过氧化物酶体增殖物激活的受体-γ信使RNA和蛋白质水平也较低。这些结果表明，随着SAMP1的老化，物理性能和能量消耗会更早降低，同时肌肉和肝脏中的脂肪酸分解代谢减少，脂肪组织中的炎症和氧化应激增加。因此，SAMP1可能是用于研究身体表现和能量代谢的有用的加速功能抑郁模型。

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