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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the cardiovascular health study all stars study.
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Longitudinal changes in adiponectin and inflammatory markers and relation to survival in the oldest old: the cardiovascular health study all stars study.

机译：脂联素和炎性标志物的纵向变化及其与最老者的存活率的关系：全明星研究心血管健康。

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BACKGROUND: Adiponectin has anti-inflammatory properties, and its production is suppressed by inflammatory factors. Although elevated levels of adiponectin and inflammatory markers each predict mortality in older adults, the implications of their interdependent actions have not been examined. METHODS: We investigated the joint associations of levels and interval changes in adiponectin, C-reactive protein (CRP), and interleukin 6 (IL-6) with risk of death in 840 older adults participating in a population-based study. Adiponectin, CRP, and IL-6 were measured in samples collected 8.9 (8.2-9.8) years apart, and all-cause mortality was subsequently ascertained (n = 176). RESULTS: Interval changes and end levels of adiponectin, CRP, and IL-6 showed mostly positive, independent associations with mortality, without evidence of multiplicative interaction. Joint models, however, showed an U-shaped relationship between end level of adiponectin and outcome (hazard ratio [HR] [95% CI] = 0.72 [0.52-0.99] per standard deviation [SD] for levels <20.0 mg/L; HR = 1.91 [1.61-3.44] per SD for levels >/=20.0 mg/L). Participants with the greatest longitudinal increases (upper quartile) in both adiponectin and inflammatory markers had a higher risk of death (HR = 2.85 [1.78-4.58]) than those with large increases in adiponectin alone (HR = 1.87 [1.20-2.92]) (p = .043), but not inflammatory markers alone (HR = 2.48 [1.67-3.67]) (p = .55), as compared with smaller changes for both. CONCLUSION: Higher levels or interval change in adiponectin and inflammatory markers predict increased mortality in older persons independent of each other, although for adiponectin, the association appears inverse below 20 mg/L. These findings suggest that inflammatory and noninflammatory mechanisms governing aging-related decline operate in parallel and provide a potential explanation for paradoxical adiponectin-outcome associations reported previously.
机译：背景：脂联素具有抗炎作用，其产生受到炎性因子的抑制。尽管脂联素和炎性标志物的水平升高均可预测老年人的死亡率，但尚未研究其相互依赖的作用的含义。方法：我们调查了参加基于人群的研究的840名老年人的脂联素，C反应蛋白（CRP）和白介素6（IL-6）的水平和间隔变化与死亡风险的联合关联。在相隔8.9（8.2-9.8）年的样本中测量脂联素，CRP和IL-6，随后确定了全因死亡率（n = 176）。结果：脂联素，CRP和IL-6的间隔变化和终末水平显示出与死亡率呈正相关，独立的相关性，而没有乘法相互作用的证据。然而，联合模型显示脂联素的终末水平与预后之间呈U型关系（水平<20.0 mg / L时，标准差[SD]的危险比[HR] [95％CI] = 0.72 [0.52-0.99];对于> / = 20.0 mg / L的水平，每个SD HR = 1.91 [1.61-3.44]。脂联素和炎性标志物纵向增加最大（上四分位数）的参与者的死亡风险（HR = 2.85 [1.78-4.58]）高于脂联素单独增加（HR = 1.87 [1.20-2.92]） （p = .043），但不包括炎性标志物（HR = 2.48 [1.67-3.67]）（p = .55），两者的变化较小。结论：脂联素和炎症标记物的较高水平或区间变化预示着彼此独立的老年人死亡率增加，尽管脂联素在20 mg / L以下呈负相关。这些发现表明，控制衰老相关衰退的炎性和非炎性机制并行运行，并为先前报道的自相矛盾的脂联素-结果关联提供了潜在的解释。

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