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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism. The KOCOA Project.
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Metabolic syndrome and cognitive decline among the oldest old in Okinawa: in search of a mechanism. The KOCOA Project.

机译：冲绳最大的老年人中的代谢综合征和认知能力下降：寻找一种机制。 KOCOA项目。

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摘要

The study aim was to test whether the metabolic syndrome or its components predicted cognitive decline among persons aged 80 years and older (mean 85.0 years). Participants were members of the "Keys to Optimal Cognitive Aging Project," a prospective cohort study in Okinawa, Japan. Metabolic syndrome was assessed at baseline. Cognitive functions were assessed annually for up to 3 years. One hundred and forty-eight participants completed at least one follow-up with 101 participating in all three assessments and 47 participating in two of the three assessments. The mean and median duration of follow-up were 1.8 and 2 years, respectively. Metabolic syndrome and four components were not associated with decline in global and executive cognitive functions. However, high glycosylated hemoglobin was associated with decline in memory function at the second follow-up. Our study supports accumulating evidence that the positive association between metabolic syndrome and cognitive function might not hold for the oldest old.
机译：该研究的目的是检验代谢综合症或其组成部分是否可以预测80岁以上（平均85.0岁）的人的认知能力下降。参加者是日本冲绳县一项前瞻性队列研究“最佳认知老化关键项目”的成员。在基线时评估代谢综合征。每年评估认知功能长达3年。 148名参与者至少完成了一次随访，其中101名参与者参加了所有三项评估，47名参与者参加了三项评估中的两项。随访的平均时间和中位时间分别为1.8年和2年。代谢综合征和四个组成部分与整体和执行认知功能的下降无关。然而，在第二次随访中，高糖基化血红蛋白与记忆功能下降有关。我们的研究支持越来越多的证据表明，代谢综合征和认知功能之间的正相关可能不适用于年龄最大的老年人。

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