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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.
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Age trends in estradiol and estrone levels measured using liquid chromatography tandem mass spectrometry in community-dwelling men of the Framingham Heart Study.

机译：在Framingham心脏研究的社区居民中，使用液相色谱串联质谱法测量的雌二醇和雌酮水平的年龄趋势。

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Age trends in estradiol and estrone levels in men and how lifestyle factors, comorbid conditions, testosterone, and sex hormone-binding globulin affect these age trends remain poorly understood, and were examined in men of the Framingham Heart Study.Estrone and estradiol concentrations were measured in morning fasting samples using liquid chromatography tandem mass spectrometry in men of Framingham Offspring Generation. Free estradiol was calculated using a law of mass action equation.There were 1,461 eligible men (mean age [±SD] 61.1±9.5 years and body mass index [BMI] 28.8±4.5kg/m(2)). Total estradiol and estrone were positively associated with age, but free estradiol was negatively associated with age. Age-related increase in total estrone was greater than that in total estradiol. Estrone was positively associated with smoking, BMI, and testosterone, and total and free estradiol with diabetes, BMI, testosterone, and comorbid conditions; additionally, free estradiol was associated negatively with smoking. Collectively, age, BMI, testosterone, and other health and behavioral factors explained only 18% of variance in estradiol, and 9% of variance in estrone levels. Men in the highest quintile of estrone levels had significantly higher age and BMI, and a higher prevalence of smoking, diabetes, and cardiovascular disease than others, whereas those in the highest quintile of estradiol had higher BMI than others.Total estrone and estradiol levels in men, measured using liquid chromatography tandem mass spectrometry, revealed significant age-related increases that were only partially accounted for by cross-sectional differences in BMI, diabetes status, and other comorbidities and health behaviors. Longitudinal studies are needed to confirm these findings.
机译：男性对雌二醇和雌酮水平的年龄趋势以及生活方式因素，合并症，睾丸激素和性激素结合球蛋白如何影响这些年龄趋势的了解仍然很少，并且在Framingham心脏研究的男性中进行了研究。测量了雌激素和雌二醇的浓度在Framingham后代的男性中使用液相色谱串联质谱法在早上的禁食样品中进行检测。游离雌二醇的计算采用质量作用方程定律。共有1,461名合格男性（平均年龄[±SD] 61.1±9.5岁，体重指数[BMI] 28.8±4.5kg / m（2））。总雌二醇和雌酮与年龄呈正相关，而游离雌二醇与年龄呈负相关。与年龄有关的总雌酮增加量大于总雌二醇。雌酮与吸烟，BMI和睾丸激素呈正相关，而总和游离雌二醇与糖尿病，BMI，睾丸激素和合并症呈正相关。另外，游离雌二醇与吸烟呈负相关。总的来说，年龄，BMI，睾丸激素以及其他健康和行为因素只能解释18％的雌二醇变化和9％的雌酮水平变化。雌酮水平最高的男性的年龄和BMI明显高于其他人群，吸烟，糖尿病和心血管疾病的患病率明显高于其他人群，而雌二醇水平最高的男性的BMI则高于其他人群。男性，使用液相色谱串联质谱法进行测量，发现与年龄相关的显着增加仅部分归因于BMI，糖尿病状况以及其他合并症和健康行为的横断面差异。需要进行纵向研究以确认这些发现。

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