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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Proteostasis and the Aging Proteome in Health and Disease
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Proteostasis and the Aging Proteome in Health and Disease

机译：蛋白质稳态和健康和疾病中的老化蛋白质组。

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The maintenance of the proteome is essential to preserve cell functionality and the ability to respond and adapt to the changing environment. This is regulated by the proteostasis network, a dedicated set of molecular components comprised of molecular chaperones and protein clearance mechanisms, regulated by cell stress signaling pathways, that prevents the toxicity associated with protein misfolding and accumulation of toxic aggregates in different subcellular compartments and tissues. The efficiency of the proteostasis network declines with age and this failure in protein homeostasis has been proposed to underlie the basis of common age-related human disorders. The current advances in the understanding of the mechanisms and regulation of proteostasis and of the different types of digressions in this process in aging have turned the attention toward the therapeutic opportunities offered by the restoration of proteostasis in age-associated degenerative diseases. Here, we discuss some of the unresolved questions on proteostasis that need to be addressed to enhance healthspan and to diminish the pathology associated with persistent protein damage.
机译：蛋白质组的维护对于保持细胞功能以及响应和适应不断变化的环境的能力至关重要。这是由蛋白质变形网络调节的，蛋白质变性网络是由分子伴侣和蛋白质清除机制组成的一组专门的分子组分，由细胞应激信号传导途径调控，可防止与蛋白质错误折叠和不同细胞亚区室和组织中有毒聚集物积累有关的毒性。蛋白质稳定网络的效率随着年龄的增长而下降，已经提出蛋白质稳态的这种失败是常见的与年龄有关的人类疾病的基础。当前对蛋白质变性的机制和调节以及衰老过程中不同类型的病变的理解的最新进展已将注意力转向由与年龄有关的变性疾病中的蛋白质变性的恢复所提供的治疗机会。在这里，我们讨论了一些有关蛋白稳态的未解决的问题，这些问题需要解决，以提高健康水平并减少与持续性蛋白质损伤相关的病理。

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