...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Neuronal vesicular trafficking and release in age-related cognitive impairment
【24h】

Neuronal vesicular trafficking and release in age-related cognitive impairment

机译：与年龄有关的认知障碍中的神经元水泡运输和释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Aging is a common major risk factor for many neurological disorders resulting in cognitive impairment and neurodegeneration including Parkinson's and Alzheimer's diseases. Novel results from the fields of molecular neuroscience and aging research provide evidence for a link between decline of various cognitive, executive functions and changes in neuronal mechanisms of intracellular trafficking and regulated vesicle release processes in the aging nervous system. In this Perspective, we review these recent findings and formulate a hypothesis on how cargo delivery to the synapses and the release of neurotrophic factors may be involved in maintaining learning and memory capabilities during healthy aging and present examples on how defects of those disrupt normal cognition. We provide an overview of emerging new concepts and approaches that will significantly advance our understanding of the aging brain and pathophysiology of dementia. This knowledge will be instrumental in defining drug targets and designing novel therapeutic strategies.
机译：衰老是许多神经系统疾病的常见主要危险因素，导致认知障碍和神经变性，包括帕金森氏症和阿尔茨海默氏病。分子神经科学和衰老研究领域的新成果为衰老的神经系统中各种认知，执行功能的下降和细胞内运输的神经元机制变化与调节的囊泡释放过程之间的联系提供了证据。在此观点中，我们回顾了这些最新发现，并提出了关于在健康衰老期间如何将货物运送至突触和释放神经营养因子与维持学习和记忆能力有关的假设，并提供了有关这些缺陷如何破坏正常认知的示例。我们提供了新出现的新概念和方法的概述，这些概念和方法将极大地增进我们对脑衰老和痴呆症的病理生理学的理解。这些知识将有助于定义药物靶标和设计新颖的治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号