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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >An evidence-based comparison of operational criteria for the presence of sarcopenia
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An evidence-based comparison of operational criteria for the presence of sarcopenia

机译：少肌症存在的手术标准的循证比较

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Background.Several consensus groups have previously published operational criteria for sarcopenia, incorporating lean mass with strength and/or physical performance. The purpose of this manuscript is to describe the prevalence, agreement, and discrepancies between the Foundation for the National Institutes of Health (FNIH) criteria with other operational definitions for sarcopenia.Methods.The FNIH Sarcopenia Project used data from nine studies including: Age, Gene and Environment Susceptibility-Reykjavik Study; Boston Puerto Rican Health Study; a series of six clinical trials from the University of Connecticut; Framingham Heart Study; Health, Aging, and Body Composition Study; Invecchiare in Chianti; Osteoporotic Fractures in Men Study; Rancho Bernardo Study; and Study of Osteoporotic Fractures. Participants included in these analyses were aged 65 and older and had measures of body mass index, appendicular lean mass, grip strength, and gait speed.Results.The prevalence of sarcopenia and agreement proportions was higher in women than men. The lowest prevalence was observed with the FNIH criteria (1.3% men and 2.3% women) compared with the International Working Group and the European Working Group for Sarcopenia in Older Persons (5.1% and 5.3% in men and 11.8% and 13.3% in women, respectively). The positive percent agreements between the FNIH criteria and other criteria were low, ranging from 7% to 32% in men and 5% to 19% in women. However, the negative percent agreement were high (all >95%).Conclusions.The FNIH criteria result in a more conservative operational definition of sarcopenia, and the prevalence was lower compared with other proposed criteria. Agreement for diagnosing sarcopenia was low, but agreement for ruling out sarcopenia was very high. Consensus on the operational criteria for the diagnosis of sarcopenia is much needed to characterize populations for study and to identify adults for treatment.
机译：背景：几个共识小组先前已发布了肌肉减少症的手术标准，将瘦体重与力量和/或身体表现相结合。本手稿的目的是描述美国国立卫生研究院基金会（FNIH）标准与少肌症的其他操作定义之间的普遍性，一致性和差异。基因与环境敏感性-雷克雅未克研究;波士顿波多黎各人健康研究;康涅狄格大学的一系列六项临床试验;弗雷明汉心脏研究;健康，衰老和身体成分研究;基安蒂的Invecchiare;男性骨质疏松性骨折研究;兰乔·伯纳多研究和骨质疏松性骨折的研究。这些研究的参与者年龄在65岁及以上，并且具有体重指数，阑尾瘦体重，抓地力和步态速度等指标。结果。女性肌肉减少症的患病率和同意率高于男性。与国际工作组和欧洲老年人肌肉减少症工作组相比，FNIH标准的患病率最低（男性为1.3％，女性为2.3％）（男性为5.1％和5.3％，女性为11.8％和13.3％ ， 分别）。 FNIH标准与其他标准之间的肯定百分比较低，男性为7％至32％，女性为5％至19％。但是，负百分比一致性很高（均大于95％）。结论：FNIH标准导致肌肉减少症的手术定义更为保守，与其他拟议标准相比，患病率较低。诊断肌肉减少症的协议很少，但排除肌肉减少症的协议很高。非常需要关于肌肉减少症诊断的操作标准的共识，以表征研究人群的特征并确定要治疗的成年人。

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