Current status of efforts to measure and modulate the biological rate of aging.

Warner HR

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Current status of efforts to measure and modulate the biological rate of aging.

机译：测量和调节生物衰老速率的努力现状。

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Biomarkers of aging would be highly desirable, but so far, a definitive panel of biomarkers to predict mortality risk has not been obtained, even though many traits that vary with age have been identified. This lack hinders the search for interventions that may retard the rate of aging in mammals. The recent discovery and characterization of many longevity genes in animal model systems, such as nematodes, fruit flies, and mice, are providing new targets for research by providing insight into mechanisms of longevity regulation in these model systems. It is hoped that this will ultimately lead to interventions to delay the development of age-related pathology in humans.

机译：衰老的生物标志物将是非常可取的，但是到目前为止，尽管已发现了许多随年龄变化的特征，但仍未获得确定死亡风险的确定性生物标志物组。这种缺乏阻碍了寻找可能会延缓哺乳动物衰老速度的干预措施。在动物模型系统中，例如线虫，果蝇和小鼠等许多寿命基因的最新发现和表征，通过深入了解这些模型系统中的寿命调节机制，为研究提供了新的目标。希望这将最终导致干预措施，以延迟人类与年龄有关的病理学的发展。

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《The journals of gerontology.Series A. Biological sciences and medical sciences》 |2004年第7期|共5页
作者
Warner HR;
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正文语种 eng
中图分类全身性疾病;
关键词
Aging; 衰老;

机译：Aging;衰老;

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Current status of efforts to measure and modulate the biological rate of aging.

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