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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >Effectiveness of nutritional supplements on cognitive functioning in elderly persons: a systematic review.
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Effectiveness of nutritional supplements on cognitive functioning in elderly persons: a systematic review.

机译：营养补充剂对老年人认知功能的有效性：系统评价。

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BACKGROUND: The effectiveness of nutritional supplementation in improving cognitive functioning is evaluated in elderly people. METHODS: The authors systematically reviewed randomized controlled trials that compared nutritional supplementation with a placebo treatment. Trials were identified from a MEDLINE search and from reference lists of identified studies and review articles. From each trial, information was gathered on the number and age of persons studied; the type, dosage, and duration of the intervention; and the assessed outcome measures. RESULTS: From 1086 titles, 571 articles were excluded based on their titles. Of the remaining 467 articles, the abstracts were read and 422 articles were excluded based on information found there. The remaining articles were screened for quality aspects of the study design, leaving 21 proper randomized, controlled trials. These trials are discussed in three groups according to the type of supplementation: multinutrient intervention or single components with or without a putative mechanism. Twelve studies, which were evenly distributed among the three supplement groups, found significantly positive effects of nutritional intervention on cognitive functioning, whereas nine studies did not. None of the studies found a significantly negative effect of nutritional intervention. CONCLUSIONS: Shortcomings in methodology varying from the duration of intervention to outcome measures partly explain discrepancies in findings. Despite the heterogeneity in trial design, the results of this review suggest that nutritional supplements may improve the cognitive functioning of elderly persons and do no harm. Further well-designed studies are needed to support these findings.
机译：背景：在老年人中评估营养补充剂改善认知功能的有效性。方法：作者系统地回顾了比较营养补充剂与安慰剂治疗的随机对照试验。通过MEDLINE搜索以及确定的研究和评论文章的参考文献列表确定试验。从每个试验中，都收集了有关研究对象的人数和年龄的信息。干预的类型，剂量和持续时间;以及评估的结果指标。结果：从1086个标题中，排除了571条文章的标题。在剩余的467篇文章中，根据那里的信息阅读了摘要，并排除了422篇文章。筛选了其余文章的研究设计质量，留下了21项适当的随机，对照试验。根据补充剂的类型，将这些试验分为三类：多营养干预或具有或不具有推定机制的单一成分。十二项研究在三个补充组之间平均分配，发现营养干预对认知功能有明显的积极影响，而九项研究则没有。没有一项研究发现营养干预有明显的负面影响。结论：从干预的持续时间到结果测量的方法学上的不足部分解释了结果的差异。尽管试验设计存在异质性，但本评价的结果表明，营养补品可能会改善老年人的认知功能，且无害。需要进一步设计良好的研究来支持这些发现。

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