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首页> 外文期刊>The journals of gerontology.Series A. Biological sciences and medical sciences >The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trial.
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The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis: a double-blind, randomized, placebo-controlled clinical trial.

机译：癸酸诺龙对骨质疏松老年妇女骨矿物质密度，肌肉质量和血红蛋白水平的影响：一项双盲，随机，安慰剂对照的临床试验。

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METHODS: In a randomized, double-blind, placebo-controlled clinical trial, we evaluated the effect of a 2-year treatment with nandrolone decanoate (ND) on bone mineral density (BMD) of lumbar spine, femoral neck, and trochanter and on vertebral fracture rate, muscle mass, and hemoglobin levels. Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND, and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily. RESULTS: Compared to baseline, ND increased the BMD of the lumbar spine (3.4% +/- 6.0 and 3.7% +/- 7.4; p < .05) and femoral neck (4.1% +/- 7.3 and 4.7% +/- 8.0; p < .05) after 1 and 2 years, respectively. The BMD of trochanter increased significantly only after the first year (4.8% +/- 9.3, p < .05). Compared to the placebo group, the ND group presented with significantly increased BMD of the trochanter and neck. ND significantly reduced incidence of new vertebral fractures (21% vs 43% in the placebo group; p < .05). ND showed a significant statistical increase in lean body mass after the first (6.2% +/- 5.8; p < .01) and second years (11.9% +/- 29.2; p < .01). In addition, a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline (14.3%; p < .01) and placebo (p < .01). CONCLUSIONS: ND increased BMD, hemoglobin levels, and muscle mass, and reduced the vertebral fracture rate of elderly osteoporotic women.
机译：方法：在一项随机，双盲，安慰剂对照的临床试验中，我们评估了癸酸诺龙（ND）治疗2年对腰椎，股骨颈和转子的骨矿物质密度（BMD）的影响，并评估了椎骨骨折率，肌肉质量和血红蛋白水平。研究了65名70岁以上的骨质疏松妇女。 32例患者接受了50 mg ND注射，每3周接受了33例安慰剂。所有患者每天接受500毫克钙片。结果：与基线相比，ND升高了腰椎的BMD（3.4％+/- 6.0和3.7％+/- 7.4; p <.05）和股骨颈（4.1％+/- 7.3和4.7％+/-） 8.0; p <.05）分别在1年和2年后。大转子的BMD仅在第一年后显着增加（4.8％+/- 9.3，p <.05）。与安慰剂组相比，ND组的转子和颈部BMD显着增加。 ND显着降低了新椎体骨折的发生率（安慰剂组为21％，而安慰剂组为43％; p <.05）。在第一年（6.2％+/- 5.8; p <.01）和第二年（11.9％+/- 29.2; p <.01）之后，ND显示出瘦体重的统计学显着增加。此外，与基线（14.3％; p <.01）和安慰剂（p <.01）相比，使用ND的2年治疗显着增加了血红蛋白水平。结论：ND增加老年骨质疏松妇女的BMD，血红蛋白水平和肌肉质量，并降低椎骨骨折率。

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