...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of rheumatology >Use of the T-SPOT.TB assay to detect latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy.
【24h】

Use of the T-SPOT.TB assay to detect latent tuberculosis infection among rheumatic disease patients on immunosuppressive therapy.

机译：使用T-SPOT.TB分析检测免疫抑制疗法在风湿性疾病患者中检测潜伏性结核感染。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: We evaluated the T-SPOT.TB assay to identify latent tuberculosis infection (LTBI) in patients with rheumatic disease receiving immunosuppressive medication including tumor necrosis factor (TNF) antagonists. METHODS: A total of 200 patients seen in the Arthritis Center at Brigham and Women's Hospital were enrolled for study. Most patients were US-born women with rheumatoid arthritis. A medical history was obtained using a questionnaire, whole blood was drawn for the T-SPOT.TB assay, and tuberculin skin testing (TST) was performed. RESULTS: Both tests were performed on 179 subjects, who had no history of a positive TST. All subjects had a strong response to the T-SPOT.TB test positive control, and there were no indeterminate results. Among these 179 subjects, 2 had a positive TST and 10 had a positive T-SPOT.TB test. No subject was positive for both tests. Patients with a positive T-SPOT.TB test did not have typical risk factors for LTBI based on clinical evaluation. CONCLUSION: The lack of concordance between the TST and the T-SPOT.TB assay may indicate that the immunoassay is more sensitive, particularly in a patient population taking immunosuppressive medications. It is equally likely that the low prevalence of LTBI in this low-risk population led to an increase in the false-positive rate despite the high sensitivity and specificity of the T-SPOT.TB assay. In the context of our patient population, the T-SPOT.TB assay is likely to be most useful in evaluation of patients with a positive TST, since these patients have a higher pretest probability of having LTBI.
机译：目的：我们评估了T-SPOT.TB分析法，以鉴定接受包括肿瘤坏死因子（TNF）拮抗剂在内的免疫抑制药物的风湿病患者的潜伏性结核感染（LTBI）。方法：共有200名患者在布莱根妇女医院关节炎中心进行了研究。大多数患者是美国出生的类风湿关节炎妇女。使用调查表获得病史，抽取全血用于T-SPOT.TB分析，并进行结核菌素皮肤测试（TST）。结果：两项测试均对179位没有TST阳性史的受试者进行。所有受试者对T-SPOT.TB测试阳性对照的反应都强烈，没有不确定的结果。在这179名受试者中，TST阳性2名，T-SPOT.TB试验阳性10名。两项测试均无受试者阳性。根据临床评估，T-SPOT.TB测试阳性的患者没有典型的LTBI危险因素。结论：TST和T-SPOT.TB测定法之间缺乏一致性可能表明免疫测定法更加灵敏，特别是在服用免疫抑制药物的患者人群中。尽管T-SPOT.TB分析具有很高的敏感性和特异性，但在这种低风险人群中LTBI的低患病率也很可能导致假阳性率增加。在我们的患者人群中，T-SPOT.TB分析可能最有用的是评估TST阳性的患者，因为这些患者患LTBI的前测可能性更高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号