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首页> 外文期刊>The Journal of rheumatology >Relative sensitivity to change of the erythrocyte sedimentation rate and serum C-reactive protein concentration in rheumatoid arthritis.
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Relative sensitivity to change of the erythrocyte sedimentation rate and serum C-reactive protein concentration in rheumatoid arthritis.

机译：类风湿关节炎对红细胞沉降率和血清C反应蛋白浓度变化的相对敏感性。

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OBJECTIVE: To compare the sensitivity to change of the erythrocyte sedimentation rate (ESR) and serum C-reactive protein (CRP) concentration used as measures of rheumatoid arthritis (RA) activity. METHODS: A literature search was conducted to identify all clinical trials and observational studies of disease-modifying medications and corticosteroids in RA that reported results for both ESR and CRP before treatment and 4 weeks to 24 weeks after treatment in the same patients. For each test, effect sizes were computed as the change in the test with treatment divided by the pretreatment standard deviation. A pooled analysis was performed on the paired differences in effect sizes for ESR and CRP within each study. RESULTS: One hundred twenty-three studies with 184 active treatment arms were identified that included measurements of both ESR and CRP. Sixty-three studies with 90 active treatment arms provided sufficient data to permit calculation of effect sizes, and were included in the analysis. In the 36 treatment arms that reported results at 12 weeks, the ESR was more sensitive to change than the CRP, with a paired difference in effect sizes of 0.09 units (95% confidence interval 0.03, 0.15; p = 0.005). In the 76 treatment arms that reported results at 24 weeks, the ESR was also more sensitive to change than the CRP, with a paired difference in effect sizes of 0.11 units (95% CI 0.05, 0.17; p = 0.0004). CONCLUSION: In these studies of disease-modifying medications in RA, the ESR was more sensitive to change than the CRP at 12 weeks and 24 weeks of treatment. Few studies examined changes in these measures at times earlier than 12 weeks.
机译：目的：比较对类风湿关节炎（RA）活性的测定方法对红细胞沉降率（ESR）和血清C反应蛋白（CRP）浓度变化的敏感性。方法：进行文献检索以鉴定RA中所有疾病改善药物和皮质类固醇的临床试验和观察性研究，这些研究报告了同一患者在治疗前和治疗后4周至24周的ESR和CRP结果。对于每个测试，将效果大小计算为治疗中测试的变化除以预处理标准偏差。对每个研究中ESR和CRP效应大小的成对差异进行汇总分析。结果：一百二十三项研究涉及184个积极的治疗组，其中包括对ESR和CRP的测量。有90个积极治疗臂的研究共进行了63次，提供了足够的数据以计算效应量，并纳入了分析。在报告第12周结果的36个治疗组中，ESR对改变的敏感性高于CRP，效应大小成对存在0.09单位的成对差异（95％置信区间0.03，0.15; p = 0.005）。在报告第24周结果的76个治疗组中，ESR比CRP还更敏感于变化，效应大小成对存在0.11个单位的成对差异（95％CI 0.05，0.17; p = 0.0004）。结论：在这些对RA的疾病缓解药物的研究中，在治疗12周和24周时，ESR比CRP对变化更敏感。很少有研究在12周之前检查这些措施的变化。

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