Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial

Dejgaard Thomas Fremming; Frandsen Christian Seerup; Hansen Tanja Stenbaek; Almdal Thomas; Urhammer Soren; Pedersen-Bjergaard Ulrik; Jensen Tonny; Jensen Andreas Kryger; Holst Jens Juul; Tarnow Lise; Knop Filip Krag; Madsbad Sten; Andersen Henrik Ullits

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Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial

机译：利拉鲁肽对超重成年1型糖尿病和血糖控制不足的成人患者的疗效和安全性（Lira-1）：一项随机，双盲，安慰剂对照试验

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Background The combination of insulin and glucagon-like peptide-1 (GLP-1) receptor agonist therapy improves glycaemic control, induces weight loss, and reduces insulin dose needed in type 2 diabetes. We assessed the efficacy and safety of the GLP-1 receptor agonist liraglutide as an add-on therapy to insulin for overweight adult patients with type 1 diabetes.

机译：背景技术胰岛素和胰高血糖素样肽1（GLP-1）受体激动剂的组合可改善血糖控制，减轻体重并减少2型糖尿病所需的胰岛素剂量。我们评估了GLP-1受体激动剂利拉鲁肽作为胰岛素超重成人1型糖尿病患者的附加疗法的有效性和安全性。

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《The lancet. Diabetes & endocrinology.》 |2016年第3期|共12页
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Dejgaard Thomas Fremming; Frandsen Christian Seerup; Hansen Tanja Stenbaek; Almdal Thomas; Urhammer Soren; Pedersen-Bjergaard Ulrik; Jensen Tonny; Jensen Andreas Kryger; Holst Jens Juul; Tarnow Lise; Knop Filip Krag; Madsbad Sten; Andersen Henrik Ullits;
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正文语种 eng
中图分类内分泌腺疾病及代谢病;
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1. Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial [J] . Dejgaard Thomas Fremming, Frandsen Christian Seerup, Hansen Tanja Stenbaek, The lancet. Diabetes & endocrinology. . 2016,第3期

机译：利拉鲁肽对超重成年1型糖尿病和血糖控制不足的成人患者的疗效和安全性（Lira-1）：一项随机，双盲，安慰剂对照试验
2. Efficacy and safety of meal-time administration of short-acting exenatide for glycaemic control in type 1 diabetes (MAG1C): a randomised, double-blind, placebo-controlled trial [J] . The lancet. Diabetes & endocrinology. . 2020,第4期

机译：1型糖尿病患者血糖对糖尿病患者膳食时间给药的疗效和安全性（MAG1C）：随机，双盲，安慰剂对照试验
3. Design and methods of a randomised double-blind trial of adding liraglutide to control HbA1c in patients with type 2 diabetes with impaired glycaemic control treated with multiple daily insulin injections (MDI-Liraglutide trial) [J] . Lind Marcus, Hirsch Irl B., Tuomilehto Jaakko, Primary care diabetes . 2015,第1期

机译：在每天两次胰岛素注射治疗的血糖控制受损的2型糖尿病患者中，加入利拉鲁肽控制HbA1c的随机双盲试验的设计和方法（MDI-利拉鲁肽试验）
4. A DOUBLE-BLIND RANDOMIZED PLACEBO-CONTROLLED CLINICAL TRIAL TO INVESTIGATE THE EFFICACY OF TIAMULIN IN THE CONTROL OF PORCINE PROLIFERATIVE ENTEROPATHY (PPE) AND PORCINE COLONIC SPIROCHAETOSIS (PCS) UNDER FIELD CONDITIONS [C] . J. Haugegaard, K. Moller, T.K. Jensen, Congress of the International Pig Veterinary Society . 2000

机译：一种双盲随机安慰剂对照临床试验，探讨硫霉素在野生植物中猪增殖肠病（PPE）和猪结肠螺旋肌肤症（PCS）的疗效
5. A Phase II, Randomized, Double-Blind, Placebo-Controlled Trial of Fish Oil (Eicosapentaenoic Acid and Docosahexaenoic Acid) on Lung and Systemic Inflammation in Patients with Acute Lung Injury. [D] . Stapleton, Renee Doney. 2010

机译：鱼油（二十碳五烯酸和二十二碳六烯酸）对急性肺损伤患者的肺和全身炎症的II期，随机，双盲，安慰剂对照试验。
6. Efficacy and safety of the glucagon-like peptide-1 receptor agonist liraglutide added to insulin therapy in poorly regulated patients with type 1 diabetes—a protocol for a randomised double-blind placebo-controlled study: The Lira-1 study [O] . Thomas Fremming Dejgaard, Filip Krag Knop, Lise Tarnow, 2015

机译：胰高血糖素样肽-1受体激动剂利拉鲁肽在胰岛素治疗中添加的胰岛素治疗对管理不善的1型糖尿病患者的疗效和安全性-一项随机双盲安慰剂对照研究的方案：Lira-1研究
7. Efficacy and safety of the glucagon-like peptide-1 receptor agonist liraglutide added to insulin therapy in poorly regulated patients with type 1 diabetes--a protocol for a randomised, double-blind, placebo-controlled study: The Lira-1 study [O] . T. F. Dejgaard, F. K. Knop, L. Tarnow, 2015

机译：胰高血糖素肽-1受体激动剂植物苷的疗效和安全性加入胰岛素治疗中的1型糖尿病患者的胰岛素治疗 - 一种用于随机，双盲，安慰剂对照研究的方案：Lira-1研究

Efficacy and safety of liraglutide for overweight adult patients with type 1 diabetes and insufficient glycaemic control (Lira-1): a randomised, double-blind, placebo-controlled trial

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