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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Health-related and specific olfaction-related quality of life in patients with chronic functional anosmia or severe hyposmia.
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Health-related and specific olfaction-related quality of life in patients with chronic functional anosmia or severe hyposmia.

机译：慢性功能性失眠或严重低渗症患者的健康相关和特定嗅觉相关的生活质量。

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OBJECTIVES/HYPOTHESIS: To measure health-related and olfaction-related quality of life (QoL) in patients with permanent, severe hyposmia or functional anosmia. STUDY DESIGN: A case study in a university ENT department of patients with severe olfactory dysfunction defined by Sniffin' Sticks olfactory test kit with a score for odor threshold, discrimination, and identification (TDI) < 20 and a dysfunction lasting longer than 6 months. METHODS: Assessment of QoL by using the SF-36 Health Survey questionnaire and the Questionnaire for Olfactory Dysfunction (QOD). RESULTS: A total of 958 patients were tested for smell disturbances from 1999 to 2009. Surveys were mailed to 527 patients who fulfilled the inclusion criteria; 280 (53%) returned completed surveys. All SF-36 domains in severely hyposmic and anosmic patients were lower than in the German normal population. Lower SF-36 QoL was found for some domains in female patients, older patients, and hyposmic patients (P < .05 for all groups). Based on the QOD, women showed more parosmia, and anosmic patients had more olfactory-related impairment (P < .05 for both); in general, higher olfactory impairment and higher parosmia score measured by QOD correlated with lower TDI values (all P < .05). Multivariate analysis revealed, for SF-36 domains, the following independent risk factors: female sex was a risk factor for bodily pain; higher age was a risk factor for physical functioning and role, bodily pain, and general health; hyposmia was a risk factor for bodily pain and mental health; QOD QoL was a risk factor for all SF-36 scales; and QOD parosmia was a risk factor for physical role (all P < .05). CONCLUSIONS: QoL is severely impaired in patients with chronic severe hyposmia or anosmia. The QOD allows a more olfaction-specific assessment of QoL than the SF-36 instrument.
机译：目的/假设：测量患有永久性，严重低渗或功能性贫血的患者的健康相关和嗅觉相关的生活质量（QoL）。研究设计：一项在大学耳鼻喉科进行的严重嗅觉功能障碍患者的案例研究，该患者由Sniffin's Sticks嗅觉测试试剂盒定义，气味阈值，辨别力和识别性（TDI）得分<20，并且功能障碍持续时间超过6个月。方法：使用SF-36健康调查问卷和嗅觉障碍问卷（QOD）评估生活质量。结果：从1999年至2009年，共对958例患者进行了嗅觉障碍检测。对符合纳入标准的527例患者进行了邮寄调查。 280（53％）人返回已完成的调查。严重低渗和厌氧患者的所有SF-36结构域均低于德国正常人群。在女性患者，老年患者和低氧患者的某些区域发现了较低的SF-36 QoL（所有组的P <.05）。根据QOD，女性表现出更多的妄想症，而厌食症患者的嗅觉相关障碍也更多（两者均P <.05）;通常，通过QOD测得的嗅觉障碍和嗅觉评分较高与较低的TDI值相关（所有P <.05）。多变量分析显示，对于SF-36域，以下独立的危险因素：女性是身体疼痛的危险因素;较高的年龄是身体机能和作用，身体疼痛和总体健康的危险因素;低渗是身体疼痛和心理健康的危险因素; QOD QoL是所有SF-36量表的危险因素; QOD妄想症是身体角色的危险因素（所有P <.05）。结论：慢性重度低渗或失眠患者的生活质量严重受损。与SF-36仪器相比，QOD可以对嗅觉进行更具体的嗅觉评估。

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