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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Empty nose syndrome: Limbic system activation observed by functional magnetic resonance imaging.
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Empty nose syndrome: Limbic system activation observed by functional magnetic resonance imaging.

机译：空鼻综合征：通过功能性磁共振成像观察到肢体系统激活。

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OBJECTIVES/HYPOTHESIS: Empty nose syndrome (ENS) patients have a persistent sense of impaired nasal patency despite radical resection of nasal turbinates. The aim of this study was to elucidate differences in cerebral activation during free breathing and after inhalation of a fragrance (lemonene) and a pseudodecongestant (menthol) over a nasofacial mask. Our hypothesis was that menthol would be perceived as beneficial and that cerebral activation would show differences in areas corresponding to emotional suffering and air hunger in ENS patients. STUDY DESIGN: Prospective, controlled intervention with lemonene and menthol during functional magnetic resonance imaging (f-MRI) experiment. METHODS: Ten right-handed ENS patients were compared to 15 controls using f-MRI and fully automated data analysis with SPM software. Nasal patency was measured with rhinomanometry and rated on a four-point scale. RESULTS: Despite similar objective nasal flow, ENS patients rated nasal patency significantly worse than did controls. Menthol was perceived to increase nasal patency. In patients, f-MRI data showed different activation of temporal cortex areas after inhalation of menthol. The comparison of patients and controls showed ENS-specific activation of temporal and cerebellar areas and amygdala during the rating task itself. CONCLUSIONS: Our experiments showed different cerebral processing of the feeling of nasal patency in ENS patients with prominent activation of areas belonging to the limbic system. The beneficial effect of menthol seems to correspond to activation differences in the temporal pole. These results demonstrate a neuronal substrate for both symptoms and their relief in ENS patients.
机译：目的/假设：尽管鼻甲的根治性切除，但空鼻综合征（ENS）患者仍存在持续性的鼻通畅感。这项研究的目的是阐明在自由呼吸期间以及在鼻面膜上吸入香精（柠檬烯）和假性减充血剂（薄荷醇）后大脑激活的差异。我们的假设是，薄荷醇会被认为是有益的，而脑部激活会在ENS患者的情绪痛苦和饥饿感对应的区域显示出差异。研究设计：在功能磁共振成像（f-MRI）实验期间，对柠檬烯和薄荷醇进行前瞻性，受控干预。方法：将10名右撇子ENS患者与15名使用f-MRI和SPM软件进行全自动数据分析的对照进行比较。鼻通畅度用鼻压力计测量并以四分制评分。结果：尽管客观的鼻腔流量相似，但ENS患者对鼻腔通畅的评价明显低于对照组。薄荷醇被认为会增加鼻腔通畅性。在患者中，f-MRI数据显示吸入薄荷醇后颞皮质区域的激活不同。对患者和对照组的比较显示，在评估任务本身期间，ENS特异性激活了颞，小脑区域和杏仁核。结论：我们的实验显示了ENS患者鼻翼通畅感觉的不同大脑加工过程，其边缘系统区域的激活明显。薄荷醇的有益作用似乎对应于颞极的激活差异。这些结果证明了ENS患者症状和缓解的神经元底物。

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