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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells
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Improvement of eustachian tube function by tissue-engineered regeneration of mastoid air cells

机译：通过组织工程性乳突空气细胞的再生改善咽鼓管功能

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Objectives/Hypothesis: Most cases of chronic otitis media (OMC) are associated with poor development of the mastoid air cells (MACs) and poor Eustachian tube (ET) function. We have previously reported that MAC regeneration can effectively eliminate intractable OMC. In this study, we assessed the ability of regenerated MACs to restore normal gas exchange function and contribute to improved ET function. Study Design: Clinical trial with control. Setting: General hospitals. Materials and Methods: Seventy-six patients with OMC, including cholesteatoma and adhesive otitis media, received tympanoplasty and MAC regeneration therapy. At the first-stage of tympanoplasty, artificial pneumatic bones and/or autologous bone fragments were implanted into the opened mastoid cavity. At the 2nd-stage operation, a nitrous oxide (N2O) gas study was performed in 10 patients to measure middle ear pressure (MEP). For the control group, MEP was measured in five patients with good MAC development during cochlear implantation or facial nerve decompression. ET function was measured twice in each patient, once before the 1st operation and 6 months after the second operation. Results: At the 2nd-stage operation, in all cases with regenerated MACs and in the normal control group, MEP changed after administration of N2O. In contrast, no change in MEP was observed in cases with unregenerated MACs. In 70% (n = 37/53) of the regenerated MAC group, ET function was improved, whereas improvement of ET function was observed in only 13% (n = 3/23) of the unregenerated MAC group. Conclusions: Tissue-engineered regeneration of MACs improves ET function and gas exchange in the middle ear. Laryngoscope, 2012
机译：目的/假设：大多数慢性中耳炎（OMC）病例与乳突空气细胞（MAC）发育不良和咽鼓管（ET）功能不良有关。我们以前曾报道过MAC再生可以有效消除顽固的OMC。在这项研究中，我们评估了再生MAC恢复正常气体交换功能并有助于改善ET功能的能力。研究设计：具有对照的临床试验。地点：综合医院。材料和方法：76例OMC患者（包括胆脂瘤和中耳炎）接受了鼓膜成形术和MAC再生治疗。在鼓室成形术的第一阶段，将人造气动骨和/或自体骨碎片植入开放的乳突腔中。在第二阶段手术中，对10例患者进行了一氧化二氮（N2O）气体研究，以测量中耳压（MEP）。对于对照组，对五名在人工耳蜗植入或面神经减压期间MAC发展良好的患者进行了MEP测量。在每例患者中两次测量ET功能，第一次手术前一次，第二次手术后6个月。结果：在第2阶段手术中，所有具有MAC再生的病例和正常对照组中，N2O给药后MEP均发生变化。相反，在未再生MAC的情况下，未观察到MEP的变化。在再生的MAC组中有70％（n = 37/53）的ET功能得到了改善，而未再生的MAC组中只有13％（n = 3/23）的ET功能得到了改善。结论：MAC的组织工程改造可改善中耳的ET功能和气体交换。喉镜，2012年

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