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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx.
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Prognostic significance of p27 expression in carcinoma of the oral cavity and oropharynx.

机译：p27表达在口腔和口咽癌中的预后意义。

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摘要

OBJECTIVE: To study the role of p27, a cyclin-dependent kinase inhibitor, as a prognostic indicator in squamous cell carcinoma of the oral cavity and oropharynx. STUDY DESIGN: Retrospective review of 35 patients with squamous cell carcinoma of the oral cavity and oropharynx who presented to Rush-Presbyterian-St. Luke's Medical Center, Chicago, Illinois, between 1986 and 1995. METHODS: Inclusion criteria were the availability of clinical information, archival pretreatment biopsy material, and a minimum follow-up of 24 months. p27 staining was scored for frequency and intensity of tumor cell expression following immunoperoxidase staining using standard techniques. Samples of squamous epithelium from the uvula of 15 nonsmoking patients without past or present squamous cell carcinoma were used as normal controls. RESULTS: The association of p27 staining and other factors with response to treatment was evaluated by Fisher's Exact Test and with overall and disease-free survival by the Kaplan-Meier method with multivariate Cox regression. Low levels of p27 expression correlated significantly with unfavorable treatment response (P<.0001), shorter overall survival (P = .0001), and shorter disease-free survival (P = .003). Tumor site (alveolus) was also associated with shorter disease-free (though not overall) survival, but the association with p27 was independent of stage and site in multivariate analysis.
机译：目的：研究细胞周期蛋白依赖性激酶抑制剂p27在口腔和口咽鳞状细胞癌中的预后指标的作用。研究设计：回顾性研究了35例口腔和口咽鳞状细胞癌患者，他们被送往Rush-Presbyterian-St。 1986年至1995年之间，位于伊利诺伊州芝加哥的卢克医学中心。方法：纳入标准为临床信息的可用性，档案预处理活检材料以及至少24个月的随访。使用标准技术对p27染色进行免疫过氧化物酶染色后，对肿瘤细胞表达的频率和强度进行评分。 15例无吸烟或无鳞状细胞癌的非吸烟者小舌的鳞状上皮样本被用作正常对照。结果：通过Fisher精确检验评估p27染色和其他因素与对治疗的反应之间的关系，并通过多变量Cox回归的Kaplan-Meier方法评估p27染色与总体生存率和无病生存率。低水平的p27表达与不良的治疗反应（P <.0001），较短的总生存期（P = .0001）和较短的无病生存期（P = .003）密切相关。肿瘤部位（肺泡）也与较短的无病生存时间（虽然不是整体）相关，但在多变量分析中，与p27的相关性与阶段和部位无关。

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