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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum.
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Fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum.

机译：磷霉素不抑制顺铂的杀伤效力。

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OBJECTIVES: This study investigates the effect of fosfomycin on the tumoricidal efficacy of cisplatinum. STUDY DESIGN: Prospective study utilizing the FaDu squamous cell carcinoma cell line and a nude mouse tumor xenograft model. METHODS: Tumor cell growth was assessed in vitro in the presence of cisplatinum and/or fosfomycin utilizing the MTT assay. An optimal cisplatinum dose and dosing schedule was established in a nude mouse tumor xenograft model of squamous cell carcinoma. Using this model, fosfomycin was tested at three dosages and tumor growth monitored over 4 weeks. RESULTS: Mice treated with cisplatinum and fosfomycin had smaller tumors than those treated with cisplatinum alone (P<.01). CONCLUSIONS: This study is the first demonstration that fosfomycin does not inhibit the tumoricidal efficacy of cisplatinum in vivo. This suggests that fosfomycin may be useful in preventing cisplatinum-induced ototoxicity and nephrotoxicity in humans without altering the tumor response rate.
机译：目的：本研究调查了磷霉素对顺铂的杀伤效果。研究设计：前瞻性研究利用FaDu鳞状细胞癌细胞系和裸鼠肿瘤异种移植模型。方法：采用MTT法在顺铂和/或磷霉素存在下体外评估肿瘤细胞的生长。在鳞状细胞癌的裸鼠肿瘤异种移植模型中建立了最佳顺铂剂量和给药方案。使用该模型，以三种剂量测试了磷霉素，并在4周内监测了肿瘤的生长。结果：用顺铂和磷霉素治疗的小鼠的肿瘤比单独用顺铂治疗的小鼠小（P <.01）。结论：这项研究是首次证明磷霉素在体内不抑制顺铂的杀伤作用。这表明磷霉素可用于预防人体内顺铂诱导的耳毒性和肾毒性，而不会改变肿瘤反应率。

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