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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Olfactory secretion and sodium, potassium-adenosine triphosphatase: regulation by corticosteroids.
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Olfactory secretion and sodium, potassium-adenosine triphosphatase: regulation by corticosteroids.

机译：嗅觉分泌和钠，钾，腺苷三磷酸钾酶：由皮质类固醇调节。

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OBJECTIVES: To investigate the cellular distribution and relative intensity of the immunoreactivity associated with the expression of sodium, potassium-adenosine triphosphatase (Na, K-ATPase) in cells of the olfactory mucosa. Second, changes in the activity of this enzyme in the olfactory mucosa are correlated with changes in the circulating corticosteroid aldosterone. METHODS: Combination of immunohistochemical and biochemical techniques were employed to examine the olfactory Na, K-ATPase. RESULTS: Within the olfactory epithelium, the Na, K-ATPase immunoreactivity was greatest at the supranuclear region of sustentacular cells and/or dendrites of olfactory receptor neurons (ORNs). Cell bodies of ORNs demonstrated moderate immunoreactivity, whereas the duct cells of Bowman's gland exhibited moderate to intense immunoreactivity. Acinar cells of the Bowman's gland were the most intensely stained components of the lamina propria, exhibiting strong immunoreactivity at the basolateral plasma membrane domains of the acinar cells and less within the cytoplasm. Binding of ouabain, a specific inhibitor of Na, K-ATPase, was significantly elevated for aldosterone-injected versus sham-injected controls. CONCLUSION: These results suggest that olfactory Na, K-ATPase is regulated by the systemic corticosteroid aldosterone. The results are consistent with the hypothesis that corticosteroids regulate olfactory secretion.
机译：目的：研究嗅觉黏膜细胞中钠，钾，腺苷三磷酸酶（Na，K-ATPase）的表达与免疫反应的细胞分布和相对强度。第二，嗅觉粘膜中该酶活性的变化与循环皮质类固醇醛固酮的变化相关。方法：结合免疫组织化学和生物化学技术检测嗅觉Na，K-ATPase。结果：在嗅上皮中，钠，K-ATP酶的免疫反应在嗅球上皮细胞和/或嗅觉受体神经元（ORNs）的树突上区域最大。 ORN的细胞体显示出中等的免疫反应性，而鲍曼氏腺的导管细胞显示出中等到强烈的免疫反应性。 Bowman腺的腺泡细胞是固有层中染色最严重的成分，在腺泡细胞的基底外侧质膜结构域表现出很强的免疫反应性，而在细胞质中则较少。相对于假注射对照组，醛固酮注射后的哇巴因（一种特殊的Na，K-ATPase抑制剂）的结合显着提高。结论：这些结果提示嗅觉Na，K-ATPase受全身性皮质类固醇醛固酮的调节。该结果与皮质类固醇调节嗅觉分泌的假设一致。

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