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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.
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Sclerotherapy with picibanil (OK-432) for congenital lymphatic malformation in the head and neck.

机译：Picibanil（OK-432）硬化疗法可治疗先天性头颈部淋巴畸形。

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HYPOTHESIS/OBJECTIVES: Congenital lymphatic malformations of the head and neck (LMHN) present special challenges to the otolaryngologist-head and neck surgeon. Recently, a number of sclerotherapy trials have shown promising results. In this study, we present our experiences with picibanil (OK-432) sclerotherapy for this lesion. STUDY DESIGN: Retrospectively review. METHODS: We retrospectively reviewed 21 patients who have undergone sclerotherapy with picibanil for LMHN. RESULTS: Satisfactory response with complete or nearly complete shrinkage of the lesions was observed in 15 cases after repeated sclerotherapy (average, two times). We did not observe any significant morbidity or complications in the patients treated with picibanil. Reduction in size of the mass was achieved in weeks to months. Some of the patients who had not had any other previous treatment showed remarkable reductions in size even after the first therapy. When we used picibanil sclerotherapy as a primary treatment for the LMHN, most of our patients showed satisfactory results regardless of the size or location of the lesions. CONCLUSION: Given with our experience and the reports that failure of picibanil sclerotherapy does not hinder subsequent surgical salvage procedures, we recommend trying picibanil sclerotherapy as a primary treatment for the LMHN and performing surgical excision as a secondary modality if the response to the sclerotherapy is not satisfactory.
机译：假设/目的：先天性头颈部淋巴畸形（LMHN）给耳鼻喉科医生，头颈外科医生带来了特殊的挑战。最近，许多硬化疗法试验显示出令人鼓舞的结果。在这项研究中，我们介绍了Picibanil（OK-432）硬化疗法治疗该病灶的经验。研究设计：回顾性审查。方法：我们回顾性回顾了21例接受皮吡苯胺硬化治疗LMHN的患者。结果：15例患者在反复进行硬化疗法后（平均，两次）观察到满意的反应，病变完全或几乎完全缩小。我们未观察到接受吡哌班治疗的患者有任何明显的发病率或并发症。在数周至数月内减小了肿块的大小。一些以前没有接受过其他治疗的患者即使在首次治疗后仍显示出明显的体型缩小。当我们使用picibanil硬化疗法作为LMHN的主要治疗方法时，无论病变的大小或位置如何，我们的大多数患者都显示出令人满意的结果。结论：根据我们的经验和报道，皮比班尼硬化疗法的失败并不妨碍随后的手术挽救程序，我们建议尝试将皮比班尼硬化疗法作为LMHN的主要治疗方法，如果对硬化疗法的反应不佳，建议将手术切除作为次要方式满意的。

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