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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Intranasal verrucous carcinoma: relationship to inverting papilloma and human papillomavirus.
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Intranasal verrucous carcinoma: relationship to inverting papilloma and human papillomavirus.

机译：鼻内疣状癌：与倒置乳头状瘤和人乳头瘤病毒有关。

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OBJECTIVES: To establish the incidence, appearance, behavior, and appropriate treatment of intranasal verrucous carcinoma and determine its relationship to inverting papilloma and human papillomavirus (HPV). STUDY DESIGN: Retrospective review of all cases of intranasal verrucous carcinoma seen at the Mayo Clinic from 1960 through May 1996. METHODS: Retrospective chart review and data collection for age, sex, smoking history, location, association with inverting papilloma, treatment, recurrence, and follow-up. Polymerase chain reaction (PCR) testing for the presence of HPV DNA was performed on all specimens. RESULTS: Of the 13 patients identified, most presented with nasal obstruction (10) or a noticeable intranasal lesion (8). The maxillary sinus was the extranasal site most often involved. Five patients had verrucous cancer develop in an inverting papilloma, and one had squamous cell carcinoma with the verrucous component (a hybrid tumor). All but one patient underwent surgery as initial treatment; only one patient had preoperative radiation therapy. Surgical procedures ranged from local excision to a craniofacial resection. Follow-up ranged from 2 months to 32 years (mean, 6.5 y). Four patients had a single recurrence and two tumors recurred a second time. No metastases developed and no one died from the tumor. In seven patients (10 specimens), DNA was successfully amplified for PCR testing, and no HPV DNA was detected. CONCLUSIONS: When verrucous tumors are discovered early, they can be treated effectively with wide local excision. In some cases, a more extensive procedure may be required. A possible role for HPV in the etiology of these tumors was not found.
机译：目的：确定鼻内疣状癌的发病率，外观，行为和适当的治疗方法，并确定其与倒置性乳头状瘤和人乳头瘤病毒（HPV）的关系。研究设计：1960年至1996年5月在梅奥诊所对鼻内疣状癌的所有病例进行回顾性研究。方法：回顾性图表回顾和数据收集，包括年龄，性别，吸烟史，位置，与乳头状瘤倒置的相关性，治疗，复发，和跟进。在所有标本上都进行了聚合酶链反应（PCR）检测是否存在HPV DNA。结果：在确定的13例患者中，大多数表现为鼻塞（10）或明显的鼻内病变（8）。上颌窦是最常累及的鼻外部位。五例患有内倒乳头状瘤的疣状癌，一名患有疣状成分的鳞状细胞癌（混合型肿瘤）。除一名患者外，所有患者均接受手术作为初始治疗。仅有一名患者术前接受过放射治疗。手术程序从局部切除到颅面切除术不等。随访时间为2个月至32年（平均6.5年）。四名患者单发复发，第二次复发了两个肿瘤。没有转移发生，没有人死于肿瘤。在7例患者（10个样本）中，成功扩增了DNA用于PCR检测，未检测到HPV DNA。结论：早期发现疣状肿瘤时，可广泛局部切除有效治疗。在某些情况下，可能需要更广泛的程序。尚未发现HPV在这些肿瘤的病因中可能的作用。

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