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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation.
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Relative risk of stroke in head and neck carcinoma patients treated with external cervical irradiation.

机译：外颈椎照射治疗的头颈部癌患者中风的相对风险。

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OBJECTIVE To determine the rate of cerebrovascular events (stroke) in patients irradiated to high doses for squamous cell carcinoma of the head and neck.STUDY DESIGN Retrospective chart review of 413 patients treated from 1987 to 2000 with squamous cell carcinoma of the head and neck was performed to determine the risk of stroke compared with the expected rate.METHODS Surgical, radiotherapeutic, radiological, and clinical or office records of 413 patients were analyzed, and data were collected regarding clinical risk factors for stroke, irradiation parameters, and follow-up on whether or not a stroke event occurred. The actuarial risk of stroke for this population was calculated and compared with expected risk from population-based data.RESULTS Of the 413 patients, 20 had strokes in follow-up, occurring between 2 and 146 months after radiotherapy. The 5-year actuarial rate of stroke was 12%, which corresponded to a relative risk of 2.09 ( =.0007) compared with the population-based "expected" data. Median radiation therapy dose was 64 Gy; there was no correlation between radiation therapy dose and stroke risk. No correlation was identified between surgery near the carotids and stroke risk.CONCLUSIONS An association between high-dose cervical irradiation for squamous cell carcinoma of the head and neck and stroke is demonstrated. Although the relative risk is approximately doubled, the absolute risk is modest in comparison to the risk of cancer recurrence. Further study of this association and possible interventions is warranted.
机译：目的确定接受大剂量头颈部鳞状细胞癌照射的患者的脑血管事件（中风）发生率。研究设计回顾性回顾性分析了1987年至2000年治疗的413例头颈部鳞状细胞癌患者。方法对413例患者的手术，放射治疗，放射学以及临床或办公室记录进行了分析，并收集了有关中风的临床危险因素，放疗参数和随访的数据。是否发生中风事件。计算了该人群的中风精算风险，并将其与基于人群的数据中的预期风险进行了比较。结果在413例患者中，有20例在随访中发生了中风，发生在放疗后2到146个月之间。 5年中风的精算率为12％，与基于人群的“预期”数据相比，相对风险为2.09（= .0007）。中位放射治疗剂量为64 Gy;放射治疗剂量和中风风险之间没有相关性。颈动脉附近的手术与中风风险之间没有相关性。结论结论头颈鳞状细胞癌的大剂量宫颈照射与中风之间存在关联。尽管相对风险大约增加了一倍，但与癌症复发的风险相比，绝对风险是中等的。有必要进一步研究这种关联和可能的干预措施。

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