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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Frozen section in a cytological diagnosis of thyroid follicular neoplasm.
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Frozen section in a cytological diagnosis of thyroid follicular neoplasm.

机译：冷冻切片在甲状腺滤泡性肿瘤的细胞学诊断中。

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OBJECTIVE/HYPOTHESIS: Fine-needle aspiration biopsy is the most accurate diagnostic test for thyroid nodules, its only limitation being the diagnosis of follicular neoplasm that does not distinguish between benign and malignant follicular lesions. STUDY DESIGN: To determine the utility of intraoperative frozen-section analysis in cases of a cytological diagnosis of follicular neoplasm, a retrospective review of 66 patients with a solitary thyroid nodule and follicular neoplasm who underwent thyroid surgery was carried out. METHODS: Fine-needle aspiration was classified following the Papanicolaou Society of Cytopathology Classification, and frozen section was defined as malignant or "deferred." If a malignant diagnosis was made by frozen-section analysis, a total thyroidectomy was carried out. The extension of thyroid surgery in the deferred cases was based on the definitive histological diagnosis. RESULTS: Sixty-four cases were classified as deferred, and two as suspect for malignancy. Among the 64 deferred cases, 15 were malignant in the final pathological findings, and 49 were benign. The two suspect cases were papillary carcinoma. Frozen-section analysis classified 2 of 17 (11.7%) cases as follicular variant of papillary carcinoma that could not be diagnosed by cytological study. However, these two cases had a strong clinical evidence of malignancy. CONCLUSION: The routine use of frozen-section analysis is useless in cases of cytological diagnosis of follicular neoplasm on fine-needle aspiration biopsy, because of the low probability of achieving the diagnosis of follicular carcinoma and the inability to provide additional information apart from the clinical and the cytological data.
机译：目的/假设：细针穿刺活检是对甲状腺结节最准确的诊断检查，其唯一的局限性是不能区分良性和恶性滤泡性病变的滤泡性肿瘤。研究设计：为了确定术中冰冻切片分析在滤泡性肿瘤细胞学诊断中的实用性，对66例行甲状腺手术的孤立性甲状腺结节和滤泡性肿瘤患者进行了回顾性研究。方法：按照帕帕尼古拉细胞病理学学会分类对细针穿刺进行分类，并将冰冻切片定义为恶性或“延缓”。如果通过冰冻切片分析做出了恶性诊断，则应进行全甲状腺切除术。延迟病例中甲状腺手术的扩展是基于明确的组织学诊断。结果：64例归为延期，2例为恶性。在64例延期病例中，有15例在最终病理结果中为恶性，而49例为良性。两个可疑病例是乳头状癌。冰冻切片分析将17例中的2例（11.7％）归类为无法通过细胞学研究诊断的乳头状癌的滤泡变体。但是，这两个案例都有强有力的恶性临床证据。结论：在细针穿刺活检的细胞学诊断滤泡性肿瘤的细胞学诊断中，常规的冷冻切片分析是无用的，因为诊断滤泡性癌的可能性较低，并且除了临床以外无法提供其他信息和细胞学数据。

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