...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Intratympanic gentamicin for intractable Meniere's disease.
【24h】

Intratympanic gentamicin for intractable Meniere's disease.

机译：鼓室内庆大霉素治疗顽固性美尼尔氏病。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

OBJECTIVE: The study aimed to analyze the results of the intratympanic injection of gentamicin as a treatment option for patients with unilateral Meniere's disease who were refractory to medical treatment. STUDY DESIGN: Prospective study in the setting of a tertiary care medical center. METHODS: Seventy-one patients with unilateral Meniere's disease according to 1995 American Academy of Otolaryngology-Head and Neck Surgery 1995 guidelines who had been unresponsive to medical therapy for at least 1 year were studied. Intratympanic injections of a prepared concentration of 27 mg/mL gentamicin were performed at weekly intervals until the development of symptoms and signs indicative of vestibular hypofunction in the treated ear. As the main outcome measure, the 1995 American Academy of Otolaryngology-Head and Neck Surgery criteria for reporting treatment outcome in Meniere's disease were used. The results of treatment were expressed in terms of control of vertigo, disability status (functional level and degree of overall impairment evaluated by the Dizziness Handicap Inventory and the University of California Los Angeles Dizziness Questionnaire), hearing level, and quantitative measurement of vestibular function. RESULTS: Vertigo was controlled in 83.1% of the 71 patients. Recurrence of vertigo spells after initially complete control was noted in 17 patients. In 13 of these patients, this was cured by another course of intratympanic injections of gentamicin. Functional level and measures of self-reported handicap were significantly and promptly lowered after treatment in the patients who attained control of vertigo. Hearing level as pure-tone average was unchanged 2 years after treatment, but hearing loss as a result of gentamicin injections occurred in 23 patients at the end of treatment and in 9 and 11 patients at 3 months and 2 years after the treatment, respectively. Vestibular function was kept normal or reduced in 49.3% of the patients, whereas in the rest of the patients vestibular areflexia was observed. Control of vertigo did not depend on the amount of vestibular damage. CONCLUSIONS: Ending weekly intratympanic injections when clinical signs of vestibular deafferentation appear can control vertigo in the majority of patients, and it is a useful alternative, together with other surgical options, for the treatment of patients with Meniere's disease who do not respond to medical treatment.
机译：目的：本研究旨在分析鼓膜内注射庆大霉素作为难治性单侧美尼尔氏病患者的治疗选择的结果。研究设计：在三级医疗中心进行前瞻性研究。方法：根据1995年美国耳鼻咽喉头颈外科学会1995年指南对71名单侧美尼尔氏病患者进行了至少一年的无药治疗研究。每周间隔鼓膜内注射浓度为27 mg / mL庆大霉素的鼓膜内注射，直至出现症状和体征，表明受治疗的耳朵出现前庭功能低下。作为主要的结局指标，使用了1995年美国耳鼻咽喉科学院的头颈部外科手术标准来报告美尼尔病的治疗结局。治疗结果表示为眩晕的控制，残疾状态（功能水平和总体损伤程度，由头昏眼花清单和加利福尼亚大学洛杉矶头晕问卷评估），听力水平和前庭功能的定量测量。结果：71例患者中有83.1％的患者得到了眩晕控制。最初完全控制后，有17例患者出现了眩晕。在这些患者中，有13名患者通过另一轮鼓内注射庆大霉素的方法治愈。治疗后获得眩晕控制的患者的功能水平和自我报告的障碍措施显着降低。治疗后2年，纯音平均听力水平没有变化，但在治疗结束后的23个月和治疗3个月和2年时分别有9例和11例患者发生了庆大霉素注射导致的听力下降。 49.3％的患者的前庭功能保持正常或降低，而其余患者则观察到前庭反射。眩晕的控制并不取决于前庭损害的程度。结论：当出现前庭脱除咖啡因的临床体征时，结束每周鼓膜内注射可以控制大多数患者的眩晕感，它是一种有用的替代方法，与其他手术方法一起用于治疗对药物没有反应的美尼尔氏病患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号