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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Tumor volume predicts outcome for advanced head and neck cancer treated with targeted chemoradiotherapy.
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Tumor volume predicts outcome for advanced head and neck cancer treated with targeted chemoradiotherapy.

机译：肿瘤体积可预测通过靶向放化疗治疗的晚期头颈癌的预后。

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OBJECTIVES/HYPOTHESIS Just as tumor volume is a prognostic indicator for local disease control among patients with head and neck cancer of intermediate size treated with radiation therapy, we hypothesized a similar association for patients with advanced disease treated with chemoradiation therapy.STUDY DESIGN Retrospective analysis of primary and nodal tumor volume was correlated with prospectively collected treatment outcome measures.METHODS Sixty-four patients with stage III-IV disease who were treated with targeted intra-arterial chemotherapy and radiation therapy (RADPLAT) were studied. Tumor volume was correlated with local disease control and survival.RESULTS Primary tumor volume correlated with local disease control and survival. The greatest risk for local failure was found among patients with primary tumor volume greater than 19.6 cc (93.8% vs. 57% [ =.001]). A nominal logistic regression analysis demonstrated primary tumor volume as being the only significant parameter related to local failure. Survival was only 14.1% among patients with primary tumor volume greater than 19.6 cc compared with 41.5% for patients with volumes less than 19.6 cc ( =.0018). A proportional hazard model indicated that the most significant and independent parameters associated with survival were primary tumor volume ( =.0007) and the site of the tumor ( =.05).CONCLUSION Tumor volume is the most important factor predictive of treatment outcome among patients with advanced head and neck cancer and should be used to stratify favorable versus unfavorable patient subsets.
机译：目的/假设就像肿瘤体积是接受放射治疗的中度头颈癌患者局部疾病控制的预后指标一样，我们假设接受化学放射治疗的晚期疾病患者也有类似的关联。研究设计回顾性分析方法：对64例经靶向动脉化疗和放射治疗（RADPLAT）治疗的III-IV期疾病患者进行研究。结果原发肿瘤体积与局部疾病的控制和生存相关。在原发肿瘤体积大于19.6 cc的患者中发现局部衰竭的最大风险（93.8％vs. 57％[= .001]）。标称逻辑回归分析表明原发肿瘤体积是与局部衰竭相关的唯一重要参数。原发肿瘤体积大于19.6 cc的患者的生存率仅为14.1％，而体积小于19.6 cc的患者为41.5％（= .0018）。比例风险模型表明，与生存相关的最重要和独立的参数是原发肿瘤体积（= .0007）和肿瘤部位（= .05）。结论肿瘤体积是预测患者治疗结果的最重要因素患有晚期头颈癌，应用于对有利与不利患者亚组进行分层。

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