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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Olfactory neuroblastoma: past, present, and future?
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Olfactory neuroblastoma: past, present, and future?

机译：嗅觉神经母细胞瘤：过去，现在和将来？

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OBJECTIVE: To consider the long-term survival and outcomes in patients with olfactory neuroblastoma undergoing craniofacial resection. STUDY DESIGN: A single-center prospective cohort study. METHODS: All patients with olfactory neuroblastoma treated in a 23-year period with craniofacial resection (with or without radiotherapy) were analyzed; a multivariate analysis was included. RESULTS: Forty-two patients aged 12 to 70 years were assessed, 83% of whom had received no preceding treatment. Craniofacial resection was used in all cases, combined with radiotherapy in 24 patients (57%). Duration of follow-up ranged from 2 to 206 months (mean follow-up period, 57 mo). The disease-free actuarial survival and overall survival were 77% and 61% at 5 years and 53% and 42% at 10 years, respectively. A Cox regression analysis identified intracranial extension and orbital involvement as independent factors affecting outcome. CONCLUSION: Craniofacial resection combined with radiotherapy offers the gold standard of care against which other approaches such as endoscopic resection must be judged.
机译：目的：考虑接受颅面切除术的嗅觉神经母细胞瘤患者的长期生存和结局。研究设计：单中心前瞻性队列研究。方法：分析了所有在23年内接受颅面切除术（有或没有放疗）的嗅觉神经母细胞瘤患者。包括多变量分析。结果：评估了42位12至70岁的患者，其中83％的患者之前未接受过治疗。所有病例均行颅面部切除术，并结合放射疗法治疗24例患者（57％）。随访时间为2到206个月（平均随访时间为57个月）。无病精算生存率和5年总生存率分别为77％和61％，以及10年生存率分别为53％和42％。 Cox回归分析确定颅内伸展和眶受累是影响预后的独立因素。结论：颅面切除术结合放射治疗提供了黄金护理标准，必须以此为依据来判断其他方法，例如内窥镜切除术。

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