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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Local administration of nitric oxide donor significantly impacts microvascular thrombosis.
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Local administration of nitric oxide donor significantly impacts microvascular thrombosis.

机译：一氧化氮供体的局部给药显着影响微血管血栓形成。

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OBJECTIVES/HYPOTHESIS: Clinical pharmacotherapy has demonstrated a role in preventing microvascular thrombosis in both experimental and clinical settings. Previous studies in the rabbit model have noted an increased rate of thrombosis with intravenous infusion of nitric oxide antagonists. The study assessed the effects of local application of nitric oxide agonists and antagonists on microvascular anastomotic patency rates. STUDY DESIGN: A randomized, prospective analysis. METHODS: An arterial inversion graft microvascular thrombosis model was used in New Zealand white rabbits. The rabbits were randomly assigned to nitric oxide agonist, antagonist, and control groups. In each rabbit, the common femoral artery was surgically exposed and a 2-mm arterial inversion graft was harvested. The anastomosis of the graft to the common femoral artery was performed in solutions of either 100 micromol/L spermine NONOate (nitric oxide donor), 100 micromol/L nitro-L-arginine-methyl ester (L-NAME) (nitric oxide synthaseinhibitor), or 0.9% sodium chloride (control) solution. The contralateral common femoral artery also underwent arterial inversion graft testing with the use of the same solution. Arterial patency was assessed 1 hour after anastomosis. RESULTS: Sixteen of 22 arterial inversion grafts performed in the spermine NONOate solution remained patent, and 6 of 22 clotted. Eleven of 21 arterial inversion grafts performed in the control solution remained patent, and 10 clotted. Seven of 21 arterial inversion grafts performed in the L-NAME solution remained patent, and 14 clotted. These results were found to be statistically significant using the chi test with a value of less than.05. CONCLUSIONS: In the rabbit model, local application of nitric oxide agonists and antagonists can significantly impact anastomotic patency rates. Further studies may demonstrate a role for the clinical use of nitric oxide in microvascular surgery.
机译：目的/假设：临床药物疗法已证明在实验和临床环境中均能预防微血管血栓形成。先前在兔子模型中进行的研究表明，静脉输注一氧化氮拮抗剂可增加血栓形成率。该研究评估了局部应用一氧化氮激动剂和拮抗剂对微血管吻合口通畅率的影响。研究设计：一项随机，前瞻性分析。方法：在新西兰白兔中使用动脉内反向移植物微血管血栓形成模型。将兔子随机分为一氧化氮激动剂，拮抗剂和对照组。在每只兔子中，通过手术暴露股总动脉，并收获2毫米动脉内翻移植物。在100 micromol / L精胺NONOate（一氧化氮供体），100 micromol / L硝基-L-精氨酸甲酯（L-NAME）（一氧化氮合酶抑制剂）的溶液中进行股总动脉的吻合或0.9％氯化钠（对照）溶液。对侧股总动脉也使用相同的溶液进行了动脉内翻试验。吻合后1小时评估动脉通畅。结果：在精胺NONOate溶液中进行的22例动脉倒置移植物中的16例仍保持专利，在22例中凝结了6例。在对照溶液中进行的21例动脉倒置移植物中的11例仍保持专利，有10例被凝结。在L-NAME溶液中进行的21例动脉倒置移植物中的7例仍处于专利保护状态，其中14例被凝结。使用chi检验发现这些结果具有统计学意义，其值小于0.05。结论：在兔模型中，局部应用一氧化氮激动剂和拮抗剂可显着影响吻合口通畅率。进一步的研究可能证明一氧化氮在微血管外科手术中的临床应用具有重要作用。

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