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首页> 外文期刊>The Laryngoscope: A Medical Journal for Clinical and Research Contributions in Otolaryngology, Head and Neck Medicine and Surgery, Facial Plastic and Reconstructive Surgery .. >Nasopharyngeal carcinoma in young patients: a systematic review of racial demographics.
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Nasopharyngeal carcinoma in young patients: a systematic review of racial demographics.

机译：青年患者的鼻咽癌：种族人口统计资料的系统评价。

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OBJECTIVES: To evaluate patients 25 years of age or younger who were treated for nasopharyngeal carcinoma. STUDY DESIGN: Retrospective review, systematic literature review. METHODS: Nasopharyngeal carcinoma (NPC) is rare in the Western world. In people younger than 30 years, it is even less common, with an incidence of 1 to 2 per million. This retrospective study was designed to analyze the outcomes of patients 25 years of age or younger who were treated for NPC at a tertiary care academic medical center. Between November 1982 and December 2004, 15 patients meeting the above criteria were treated. These patients form the basis for this report. A systematic review of all NPC trials published in the United States since 1990 was done and the results compared with those of our cohort. RESULTS: Young African Americans represented 67% of the 15 cases seen at our institution and between 55% and 67% of the patients in the United States. With a mean follow-up of 5.36 years, disease-free survival and overall survival rates were 67% and 87%, respectively. Locoregional control was excellent after treatment with cisplatin-based combination chemoradiotherapy; however, four patients (27%) developed distant metastasis. Despite this, no patients died of disease. Toxicity was significant but manageable, and retreatment met with good success. CONCLUSIONS: In patients 25 years of age or younger, NPC is more common in African Americans. This may represent a genetic and racial predisposition of this unusual disease in the United States. Late-stage presentations and distant recurrences are common. Platinum-based combination chemoradiotherapy and aggressive management of metastatic disease, however, is associated with good long-term survival. Further study of the possibly changing epidemiology and racial genetics of this unusual tumor is warranted.
机译：目的：评估接受鼻咽癌治疗的25岁以下的患者。研究设计：回顾性回顾，系统的文献回顾。方法：鼻咽癌（NPC）在西方世界很少见。在30岁以下的人群中，这种疾病的发病率甚至更低，每百万人中有1-2人发病。这项回顾性研究旨在分析在三级医疗学术医学中心接受过NPC治疗的25岁以下的患者的结局。在1982年11月至2004年12月之间，治疗了15例符合上述标准的患者。这些患者构成了本报告的基础。对1990年以来在美国发布的所有NPC试验进行了系统的综述，并将结果与​​我们同类研究的结果进行了比较。结果：在我们机构所见的15例患者中，年轻的非洲裔美国人占67％，在美国则占55％至67％。平均随访5.36年，无病生存率和总生存率分别为67％和87％。基于顺铂的联合放化疗治疗后，局部区域控制非常好;但是，有4名患者（27％）发生了远处转移。尽管如此，没有患者死于疾病。毒性很大但可控，再治疗取得了成功。结论：在25岁以下的患者中，NPC在非洲裔美国人中更为常见。这可能代表了美国这种不寻常疾病的遗传和种族易感性。后期表现和远处复发是常见的。然而，基于铂的联合放化疗和积极治疗转移性疾病与良好的长期生存相关。因此，有必要对这种罕见肿瘤的流行病学和种族遗传学进行进一步研究。

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